CNGA4

From Wikipedia, the free encyclopedia

Cyclic nucleotide gated channel alpha 4

Identifiers

CNGA4; CNCA2; CNG5; CNGB2; MGC126168; MGC126169; OCNC2; OCNCBETA; OCNCb

External IDs

OMIM: 609472 MGI: 2664099 HomoloGene: 13579

Gene ontology
Molecular Function:	• ion channel activity • voltage-gated potassium channel activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• ion transport • potassium ion transport

Orthologs

Human

Mouse

Refseq

NM_001037329 (mRNA)
NP_001032406 (protein)

NM_001033317 (mRNA)
NP_001028489 (protein)

Location

Chr 11: 6.21 - 6.22 Mb

Chr 7: 105.28 - 105.28 Mb

Pubmed search

[1]

[2]

Cyclic nucleotide gated channel alpha 4, also known as CNGA4, is a human gene.^[1]

CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: CNGA4 cyclic nucleotide gated channel alpha 4.

[edit] Further reading

Hofmann F, Biel M, Kaupp UB (2006). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.". Pharmacol. Rev. 57 (4): 455-62. doi:10.1124/pr.57.4.8. PMID 16382102.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Kelliher KR, Ziesmann J, Munger SD, et al. (2003). "Importance of the CNGA4 channel gene for odor discrimination and adaptation in behaving mice.". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 4299-304. doi:10.1073/pnas.0736071100. PMID 12649326.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Bradley J, Frings S, Yau KW, Reed R (2002). "Nomenclature for ion channel subunits.". Science 294 (5549): 2095-6. PMID 11764791.
Munger SD, Lane AP, Zhong H, et al. (2002). "Central role of the CNGA4 channel subunit in Ca2+-calmodulin-dependent odor adaptation.". Science 294 (5549): 2172-5. doi:10.1126/science.1063224. PMID 11739959.
Sautter A, Zong X, Hofmann F, Biel M (1998). "An isoform of the rod photoreceptor cyclic nucleotide-gated channel beta subunit expressed in olfactory neurons.". Proc. Natl. Acad. Sci. U.S.A. 95 (8): 4696-701. PMID 9539801.