CMTM2

From Wikipedia, the free encyclopedia

CKLF-like MARVEL transmembrane domain containing 2

Identifiers

CMTM2; CKLFSF2; MGC39436

External IDs

OMIM: 607885 MGI: 2447311 HomoloGene: 88915

Gene ontology
Molecular Function:	• cytokine activity
Cellular Component:	• extracellular space • membrane • integral to membrane
Biological Process:	• chemotaxis

Orthologs

Human

Mouse

Refseq

NM_144673 (mRNA)
NP_653274 (protein)

XM_993919 (mRNA)
XP_999013 (protein)

Location

Chr 16: 65.17 - 65.18 Mb

Chr 8: 107.21 - 107.22 Mb

Pubmed search

[1]

[2]

CKLF-like MARVEL transmembrane domain containing 2, also known as CMTM2, is a human gene.^[1]

This gene belongs to the chemokine-like factor gene superfamily, a novel family that links the chemokine and the transmembrane 4 superfamilies of signaling molecules. The protein encoded by this gene may play an important role in testicular development.^[1]

[edit] References

^ ^a ^b Entrez Gene: CMTM2 CKLF-like MARVEL transmembrane domain containing 2.

[edit] Further reading

Liu G, Xin ZC, Chen L, et al. (2007). "Expression and localization of CKLFSF2 in human spermatogenesis.". Asian J. Androl. 9 (2): 189-98. doi:10.1111/j.1745-7262.2007.00249.x. PMID 17334588.
Shi S, Rui M, Han W, et al. (2005). "CKLFSF2 is highly expressed in testis and can be secreted into the seminiferous tubules.". Int. J. Biochem. Cell Biol. 37 (8): 1633-40. doi:10.1016/j.biocel.2004.04.028. PMID 15896670.
Xu M, Yang S, Gao Y, et al. (2005). "A functional promoter region of the CKLFSF2 gene is located in the last intron/exon region of the upstream CKLFSF1 gene.". Int. J. Biochem. Cell Biol. 37 (6): 1296-307. doi:10.1016/j.biocel.2005.01.004. PMID 15778092.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Han W, Ding P, Xu M, et al. (2004). "Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation.". Genomics 81 (6): 609-17. PMID 12782130.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Denef B, Werf FV, Geest HD, Kesteloot H (1976). "Calibrated apexcardiography and assessment of left ventricular dynamics in man.". European journal of cardiology 4 Suppl: 143-52. PMID 1278213.