CMAS (gene)

From Wikipedia, the free encyclopedia

Cytidine monophosphate N-acetylneuraminic acid synthetase

PDB rendering based on 1qwj.

Available structures: 1qwj

Identifiers

Symbol(s)

CMAS;

External IDs

OMIM: 603316 MGI: 1337124 HomoloGene: 7670

Gene ontology
Molecular Function:	• N-acylneuraminate cytidylyltransferase activity • transferase activity
Cellular Component:	• nucleus
Biological Process:	• lipopolysaccharide biosynthetic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018686 (mRNA)
NP_061156 (protein)

NM_009908 (mRNA)
NP_034038 (protein)

Location

Chr 12: 22.09 - 22.11 Mb

Chr 6: 142.71 - 142.73 Mb

Pubmed search

[1]

[2]

Cytidine monophosphate N-acetylneuraminic acid synthetase, also known as CMAS, is a human gene.^[1]

The enzyme encoded by this gene catalyzes the activation of Neu5Ac to Cytidine 5-prime-monophosphate N-acetylneuraminic acid (CMP-Neu5Ac), which provides the substrate required for the addition of sialic acid. Sialic acids of cell surface glycoproteins and glycolipids play a pivotal role in the structure and function of animal tissues. The pattern of cell surface sialylation is highly regulated during embryonic development, and changes with stages of differentiation. Studies of a similar murine protein suggest that this protein localizes to the nucleus.^[1]

[edit] References

^ ^a ^b Entrez Gene: CMAS cytidine monophosphate N-acetylneuraminic acid synthetase.

[edit] Further reading

Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.". Nature 377 (6547 Suppl): 3-174. PMID 7566098.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807-28. PMID 8889549.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Münster AK, Eckhardt M, Potvin B, et al. (1998). "Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs.". Proc. Natl. Acad. Sci. U.S.A. 95 (16): 9140-5. PMID 9689047.
Angata T, Varki NM, Varki A (2001). "A second uniquely human mutation affecting sialic acid biology.". J. Biol. Chem. 276 (43): 40282-7. doi:10.1074/jbc.M105926200. PMID 11546777.
Lawrence SM, Huddleston KA, Tomiya N, et al. (2002). "Cloning and expression of human sialic acid pathway genes to generate CMP-sialic acids in insect cells.". Glycoconj. J. 18 (3): 205-13. PMID 11602804.
Munster AK, Weinhold B, Gotza B, et al. (2002). "Nuclear localization signal of murine CMP-Neu5Ac synthetase includes residues required for both nuclear targeting and enzymatic activity.". J. Biol. Chem. 277 (22): 19688-96. doi:10.1074/jbc.M201093200. PMID 11893746.
Kutsenko AS, Gizatullin RZ, Al-Amin AN, et al. (2002). "NotI flanking sequences: a tool for gene discovery and verification of the human genome.". Nucleic Acids Res. 30 (14): 3163-70. PMID 12136098.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.