CLNS1A

From Wikipedia, the free encyclopedia

Chloride channel, nucleotide-sensitive, 1A

PDB rendering based on 1zyi.

Available structures: 1zyi

Identifiers

Symbol(s)

CLNS1A; CLNS1B; ICln; CLCI

External IDs

OMIM: 602158 MGI: 109638 HomoloGene: 990

Gene ontology
Molecular Function:	• auxiliary transport protein activity
Cellular Component:	• nucleus • plasma membrane
Biological Process:	• transport • chloride transport • regulation of cell volume • visual perception • circulation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001293 (mRNA)
NP_001284 (protein)

NM_023671 (mRNA)
NP_076160 (protein)

Location

Chr 11: 77 - 77.03 Mb

Chr 7: 97.57 - 97.59 Mb

Pubmed search

[1]

[2]

Chloride channel, nucleotide-sensitive, 1A, also known as CLNS1A, is a human gene.^[1]

[edit] References

^ Entrez Gene: CLNS1A chloride channel, nucleotide-sensitive, 1A.

[edit] Further reading

Calinisan V, Gravem D, Chen RP, et al. (2006). "New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium.". Front. Biosci. 11: 1646–66. PMID 16368544.
Anguita J, Chalfant ML, Civan MM, Coca-Prados M (1995). "Molecular cloning of the human volume-sensitive chloride conductance regulatory protein, pICln, from ocular ciliary epithelium.". Biochem. Biophys. Res. Commun. 208 (1): 89–95. PMID 7887970.
Buyse G, de Greef C, Raeymaekers L, et al. (1996). "The ubiquitously expressed pICln protein forms homomeric complexes in vitro.". Biochem. Biophys. Res. Commun. 218 (3): 822–7. doi:10.1006/bbrc.1996.0146. PMID 8579598.
Nagl UO, Erdel M, Schmarda A, et al. (1997). "Chromosomal localization of the genes (CLNS1A and CLNS1B) coding for the swelling-dependent chloride channel ICln.". Genomics 38 (3): 438–41. doi:10.1006/geno.1996.0651. PMID 8975725.
Schwartz RS, Rybicki AC, Nagel RL (1997). "Molecular cloning and expression of a chloride channel-associated protein pICln in human young red blood cells: association with actin.". Biochem. J. 327 ( Pt 2): 609–16. PMID 9359436.
Bekri S, Adélaïde J, Merscher S, et al. (1998). "Detailed map of a region commonly amplified at 11q13-->q14 in human breast carcinoma.". Cytogenet. Cell Genet. 79 (1-2): 125–31. PMID 9533029.
Krapivinsky G, Pu W, Wickman K, et al. (1998). "pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology.". J. Biol. Chem. 273 (18): 10811–4. PMID 9556550.
Tang CJ, Tang TK (1998). "The 30-kD domain of protein 4.1 mediates its binding to the carboxyl terminus of pICln, a protein involved in cellular volume regulation.". Blood 92 (4): 1442–7. PMID 9694734.
Pu WT, Krapivinsky GB, Krapivinsky L, Clapham DE (1999). "pICln inhibits snRNP biogenesis by binding core spliceosomal proteins.". Mol. Cell. Biol. 19 (6): 4113–20. PMID 10330151.
Hubert MD, Levitan I, Hoffman MM, et al. (2000). "Modulation of volume regulated anion current by I(Cln).". Biochim. Biophys. Acta 1466 (1-2): 105–14. PMID 10825435.
Friesen WJ, Paushkin S, Wyce A, et al. (2001). "The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins.". Mol. Cell. Biol. 21 (24): 8289–300. doi:10.1128/MCB.21.24.8289-8300.2001. PMID 11713266.
Meister G, Eggert C, Bühler D, et al. (2002). "Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln.". Curr. Biol. 11 (24): 1990–4. PMID 11747828.
Friesen WJ, Wyce A, Paushkin S, et al. (2002). "A novel WD repeat protein component of the methylosome binds Sm proteins.". J. Biol. Chem. 277 (10): 8243–7. doi:10.1074/jbc.M109984200. PMID 11756452.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Meyer G, Rodighiero S, Guizzardi F, et al. (2004). "Volume-regulated Cl- channels in human pleural mesothelioma cells.". FEBS Lett. 559 (1-3): 45–50. doi:10.1016/S0014-5793(04)00020-1. PMID 14960305.
Larkin D, Murphy D, Reilly DF, et al. (2004). "ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation.". J. Biol. Chem. 279 (26): 27286–93. doi:10.1074/jbc.M402159200. PMID 15075326.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Fürst J, Schedlbauer A, Gandini R, et al. (2005). "ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4.". J. Biol. Chem. 280 (35): 31276–82. doi:10.1074/jbc.M500541200. PMID 15905169.
Azzouz TN, Pillai RS, Däpp C, et al. (2005). "Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes.". J. Biol. Chem. 280 (41): 34435–40. doi:10.1074/jbc.M505077200. PMID 16087681.