CLIP2

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CAP-GLY domain containing linker protein 2
PDB rendering based on 2cp2.
Available structures: 2cp2, 2cp3
Identifiers
Symbol(s) CLIP2; CLIP; CLIP-115; CYLN2; KIAA0291; MGC11333; WBSCR4; WSCR4
External IDs OMIM: 603432 MGI: 1313136 HomoloGene: 20718
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 7461 269713
Ensembl ENSG00000106665 ENSMUSG00000063146
Uniprot Q9UDT6 Q9Z0H8
Refseq NM_003388 (mRNA)
NP_003379 (protein)		 NM_001039162 (mRNA)
NP_001034251 (protein)
Location Chr 7: 73.34 - 73.46 Mb Chr 5: 134.78 - 134.82 Mb
Pubmed search [1] [2]

CAP-GLY domain containing linker protein 2, also known as CLIP2, is a human gene.[1]

The protein encoded by this gene belongs to the family of cytoplasmic linker proteins, which have been proposed to mediate the interaction between specific membranous organelles and microtubules. This protein was found to associate with both microtubules and an organelle called the dendritic lamellar body. This gene is hemizygously deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants.[1]

[edit] References

  1. ^ a b Entrez Gene: CLIP2 CAP-GLY domain containing linker protein 2.

[edit] Further reading

  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99-106. PMID 12168954. 
  • Osborne LR, Martindale D, Scherer SW, et al. (1997). "Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients.". Genomics 36 (2): 328-36. doi:10.1006/geno.1996.0469. PMID 8812460. 
  • Ohara O, Nagase T, Ishikawa K, et al. (1997). "Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins.". DNA Res. 4 (1): 53-9. PMID 9179496. 
  • Hoogenraad CC, Eussen BH, Langeveld A, et al. (1998). "The murine CYLN2 gene: genomic organization, chromosome localization, and comparison to the human gene that is located within the 7q11.23 Williams syndrome critical region.". Genomics 53 (3): 348-58. doi:10.1006/geno.1998.5529. PMID 9799601. 
  • "Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097-108. PMID 9847074. 
  • Corper AL, Stratmann T, Apostolopoulos V, et al. (2000). "A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes.". Science 288 (5465): 505-11. PMID 10775108. 
  • Akhmanova A, Hoogenraad CC, Drabek K, et al. (2001). "Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts.". Cell 104 (6): 923-35. PMID 11290329. 
  • Hoogenraad CC, Koekkoek B, Akhmanova A, et al. (2002). "Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice.". Nat. Genet. 32 (1): 116-27. doi:10.1038/ng954. PMID 12195424. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157-64. doi:10.1038/nature01782. PMID 12853948. 
  • Navarro-Lérida I, Martínez Moreno M, Roncal F, et al. (2004). "Proteomic identification of brain proteins that interact with dynein light chain LC8.". Proteomics 4 (2): 339-46. doi:10.1002/pmic.200300528. PMID 14760703. 
  • Evgrafov OV, Mersiyanova I, Irobi J, et al. (2004). "Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy.". Nat. Genet. 36 (6): 602-6. doi:10.1038/ng1354. PMID 15122254. 
  • Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution.". Science 308 (5725): 1149-54. doi:10.1126/science.1108625. PMID 15790807. 
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635-48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
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