CLIC6

From Wikipedia, the free encyclopedia

Chloride intracellular channel 6

Identifiers

CLIC6; CLIC1L

External IDs

Gene ontology
Molecular Function:	• voltage-gated chloride channel activity • chloride ion binding
Cellular Component:	• membrane
Biological Process:	• ion transport • chloride transport

Orthologs

Human

Mouse

Refseq

NM_053277 (mRNA)
NP_444507 (protein)

NM_172469 (mRNA)
NP_766057 (protein)

Location

Chr 21: 34.96 - 35.01 Mb

Chr 16: 92.39 - 92.43 Mb

Pubmed search

[1]

[2]

Chloride intracellular channel 6, also known as CLIC6, is a human gene.^[1]

This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. An alternatively spliced transcript variant has been described, but its biological validity has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: CLIC6 chloride intracellular channel 6.

[edit] Further reading

Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807-28. PMID 8889549.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311-9. doi:10.1038/35012518. PMID 10830953.
Strippoli P, D'Addabbo P, Lenzi L, et al. (2003). "Segmental paralogy in the human genome: a large-scale triplication on 1p, 6p, and 21q.". Mamm. Genome 13 (8): 456-62. doi:10.1007/s00335-001-2157-0. PMID 12226712.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Scanlan MJ, Gout I, Gordon CM, et al. (2003). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression.". Cancer Immun. 1: 4. PMID 12747765.
Griffon N, Jeanneteau F, Prieur F, et al. (2003). "CLIC6, a member of the intracellular chloride channel family, interacts with dopamine D(2)-like receptors.". Brain Res. Mol. Brain Res. 117 (1): 47-57. PMID 14499480.
Friedli M, Guipponi M, Bertrand S, et al. (2004). "Identification of a novel member of the CLIC family, CLIC6, mapping to 21q22.12.". Gene 320: 31-40. PMID 14597386.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.