CLIC5

From Wikipedia, the free encyclopedia

Chloride intracellular channel 5

Identifiers

CLIC5; CLIC5B; FLJ90663; MST130; MSTP130; dJ447E21.4

External IDs

OMIM: 607293 MGI: 1917912 HomoloGene: 987

Gene ontology
Molecular Function:	• voltage-gated chloride channel activity • protein binding • chloride ion binding
Cellular Component:	• insoluble fraction • microvillus • actin cytoskeleton • membrane
Biological Process:	• ion transport • chloride transport • female pregnancy

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016929 (mRNA)
NP_058625 (protein)

NM_172621 (mRNA)
NP_766209 (protein)

Location

Chr 6: 45.98 - 46.16 Mb

Chr 17: 43.65 - 43.74 Mb

Pubmed search

[1]

[2]

Chloride intracellular channel 5, also known as CLIC5, is a human gene.^[1]

Chloride intracellular channels are involved in chloride ion transport within various subcellular compartments. CLIC5 specifically associates with the cytoskeleton of placenta microvilli.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: CLIC5 chloride intracellular channel 5.

[edit] Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Berryman M, Bretscher A (2000). "Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli.". Mol. Biol. Cell 11 (5): 1509–21. PMID 10793131.
Shanks RA, Larocca MC, Berryman M, et al. (2002). "AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member.". J. Biol. Chem. 277 (43): 40973–80. doi:10.1074/jbc.M112277200. PMID 12163479.
Suzuki T, Morita R, Sugimoto Y, et al. (2002). "Identification and mutational analysis of candidate genes for juvenile myoclonic epilepsy on 6p11-p12: LRRC1, GCLC, KIAA0057 and CLIC5.". Epilepsy Res. 50 (3): 265–75. PMID 12200217.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Berryman M, Bruno J, Price J, Edwards JC (2004). "CLIC-5A functions as a chloride channel in vitro and associates with the cortical actin cytoskeleton in vitro and in vivo.". J. Biol. Chem. 279 (33): 34794–801. doi:10.1074/jbc.M402835200. PMID 15184393.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Gonzalez A, Ciobanu D, Sayers M, et al. (2007). "Gene transcript amplification from cell lysates in continuous-flow microfluidic devices.". Biomedical microdevices 9 (5): 729–36. doi:10.1007/s10544-007-9083-1. PMID 17492382.