CLIC1

From Wikipedia, the free encyclopedia

Chloride intracellular channel 1

PDB rendering based on 1k0m.

Available structures: 1k0m, 1k0n, 1k0o, 1rk4

Identifiers

Symbol(s)

CLIC1; G6; NCC27

External IDs

OMIM: 602872 MGI: 2148924 HomoloGene: 20343

Gene ontology
Molecular Function:	• voltage-gated chloride channel activity • protein binding • chloride ion binding
Cellular Component:	• membrane fraction • soluble fraction • nucleus • nuclear envelope • cytoplasm • brush border • membrane
Biological Process:	• ion transport • chloride transport • signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001288 (mRNA)
NP_001279 (protein)

NM_033444 (mRNA)
NP_254279 (protein)

Location

Chr c6_COX: 31.83 - 31.84 Mb

Chr 17: 34.66 - 34.67 Mb

Pubmed search

[1]

[2]

Chloride intracellular channel 1, also known as CLIC1, is a human gene.^[1]

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity.^[1]

[edit] References

^ ^a ^b Entrez Gene: CLIC1 chloride intracellular channel 1.

[edit] Further reading

Okubo K, Hori N, Matoba R, et al. (1994). "Large scale cDNA sequencing for analysis of quantitative and qualitative aspects of gene expression.". Nat. Genet. 2 (3): 173–9. doi:10.1038/ng1192-173. PMID 1345164.
Frigerio JM, Berthézène P, Garrido P, et al. (1995). "Analysis of 2166 clones from a human colorectal cancer cDNA library by partial sequencing.". Hum. Mol. Genet. 4 (1): 37–43. PMID 7711732.
Liew CC, Hwang DM, Fung YW, et al. (1994). "A catalogue of genes in the cardiovascular system as identified by expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 91 (22): 10645–9. PMID 7938007.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
Valenzuela SM, Martin DK, Por SB, et al. (1997). "Molecular cloning and expression of a chloride ion channel of cell nuclei.". J. Biol. Chem. 272 (19): 12575–82. PMID 9139710.
Heiss NS, Poustka A (1997). "Genomic structure of a novel chloride channel gene, CLIC2, in Xq28.". Genomics 45 (1): 224–8. doi:10.1006/geno.1997.4922. PMID 9339381.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
Tulk BM, Edwards JC (1998). "NCC27, a homolog of intracellular Cl- channel p64, is expressed in brush border of renal proximal tubule.". Am. J. Physiol. 274 (6 Pt 2): F1140–9. PMID 9841507.
Chuang JZ, Milner TA, Zhu M, Sung CH (1999). "A 29 kDa intracellular chloride channel p64H1 is associated with large dense-core vesicles in rat hippocampal neurons.". J. Neurosci. 19 (8): 2919–28. PMID 10191309.
Ribas G, Neville M, Wixon JL, et al. (1999). "Genes encoding three new members of the leukocyte antigen 6 superfamily and a novel member of Ig superfamily, together with genes encoding the regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-kb segment of the MHC class III region.". J. Immunol. 163 (1): 278–87. PMID 10384126.
Berryman M, Bretscher A (2000). "Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli.". Mol. Biol. Cell 11 (5): 1509–21. PMID 10793131.
Tonini R, Ferroni A, Valenzuela SM, et al. (2000). "Functional characterization of the NCC27 nuclear protein in stable transfected CHO-K1 cells.". FASEB J. 14 (9): 1171–8. PMID 10834939.
Valenzuela SM, Mazzanti M, Tonini R, et al. (2001). "The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle.". J. Physiol. (Lond.) 529 Pt 3: 541–52. PMID 11195932.
Harrop SJ, DeMaere MZ, Fairlie WD, et al. (2002). "Crystal structure of a soluble form of the intracellular chloride ion channel CLIC1 (NCC27) at 1.4-A resolution.". J. Biol. Chem. 276 (48): 44993–5000. doi:10.1074/jbc.M107804200. PMID 11551966.
Warton K, Tonini R, Fairlie WD, et al. (2002). "Recombinant CLIC1 (NCC27) assembles in lipid bilayers via a pH-dependent two-state process to form chloride ion channels with identical characteristics to those observed in Chinese hamster ovary cells expressing CLIC1.". J. Biol. Chem. 277 (29): 26003–11. doi:10.1074/jbc.M203666200. PMID 11978800.
Shanks RA, Larocca MC, Berryman M, et al. (2002). "AKAP350 at the Golgi apparatus. II. Association of AKAP350 with a novel chloride intracellular channel (CLIC) family member.". J. Biol. Chem. 277 (43): 40973–80. doi:10.1074/jbc.M112277200. PMID 12163479.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Fan L, Yu W, Zhu X (2003). "Interaction of Sedlin with chloride intracellular channel proteins.". FEBS Lett. 540 (1-3): 77–80. PMID 12681486.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6.". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
Littler DR, Harrop SJ, Fairlie WD, et al. (2004). "The intracellular chloride ion channel protein CLIC1 undergoes a redox-controlled structural transition.". J. Biol. Chem. 279 (10): 9298–305. doi:10.1074/jbc.M308444200. PMID 14613939.