CLEC2B

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It has been suggested that this article or section be merged with CLEC1B. (Discuss)

C-type lectin domain family 2, member B

Identifiers

Symbol(s)

CLEC2B; AICL; CLECSF2; HP10085; IFNRG1

External IDs

OMIM: 603242 HomoloGene: 68443

Gene ontology
Molecular Function:	• sugar binding
Cellular Component:	• integral to plasma membrane • membrane
Biological Process:	• antimicrobial humoral response

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_005127 (mRNA)
NP_005118 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 12: 9.9 - 9.91 Mb

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Pubmed search

[1]

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C-type lectin domain family 2, member B, also known as CLEC2B, is a human gene.^[1]

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell activation antigen. An alternative splice variant has been described but its full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.^[1]

[edit] References

^ ^a ^b Entrez Gene: CLEC2B C-type lectin domain family 2, member B.

[edit] Further reading

Drickamer K (1999). "C-type lectin-like domains.". Curr. Opin. Struct. Biol. 9 (5): 585-90. PMID 10508765.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ebner S, Sharon N, Ben-Tal N (2003). "Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily.". Proteins 53 (1): 44-55. doi:10.1002/prot.10440. PMID 12945048.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Renedo M, Arce I, Montgomery K, et al. (2000). "A sequence-ready physical map of the region containing the human natural killer gene complex on chromosome 12p12.3-p13.2.". Genomics 65 (2): 129-36. doi:10.1006/geno.2000.6163. PMID 10783260.
Yokoyama-Kobayashi M, Yamaguchi T, Sekine S, Kato S (1999). "Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank.". Gene 228 (1-2): 161-7. PMID 10072769.
Hamann J, Montgomery KT, Lau S, et al. (1997). "AICL: a new activation-induced antigen encoded by the human NK gene complex.". Immunogenetics 45 (5): 295-300. PMID 9038101.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548.