CLEC1B

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It has been suggested that this article or section be merged with CLEC2B. (Discuss)

C-type lectin domain family 1, member B

PDB rendering based on 2c6u.

Available structures: 2c6u

Identifiers

Symbol(s)

CLEC1B; CLEC2B; 1810061I13Rik; CLEC2; PRO1384; QDED721

External IDs

OMIM: 606783 MGI: 1913287 HomoloGene: 49468

Gene ontology
Molecular Function:	• transmembrane receptor activity • sugar binding
Cellular Component:	• integral to plasma membrane
Biological Process:	• defense response • cell surface receptor linked signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_016509 (mRNA)
NP_057593 (protein)

NM_019985 (mRNA)
NP_064369 (protein)

Location

Chr 12: 10.04 - 10.06 Mb

Chr 6: 129.36 - 129.37 Mb

Pubmed search

[1]

[2]

C-type lectin domain family 1, member B, also known as CLEC1B and CLEC-2, is a human gene.^[1]

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: CLEC1B C-type lectin domain family 1, member B.

[edit] Further reading

Colonna M, Samaridis J, Angman L (2000). "Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells.". Eur. J. Immunol. 30 (2): 697–704. doi:10.1002/1521-4141(200002)30:2<697::AID-IMMU697>3.0.CO;2-M. PMID 10671229.
Sobanov Y, Bernreiter A, Derdak S, et al. (2002). "A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex.". Eur. J. Immunol. 31 (12): 3493–503. PMID 11745369.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Suzuki-Inoue K, Fuller GL, García A, et al. (2006). "A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2.". Blood 107 (2): 542–9. doi:10.1182/blood-2005-05-1994. PMID 16174766.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Watson AA, O'Callaghan CA (2006). "Crystallization and X-ray diffraction analysis of human CLEC-2.". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61 (Pt 12): 1094–6. doi:10.1107/S1744309105037991. PMID 16511244.
Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12.". Nature 440 (7082): 346–51. doi:10.1038/nature04569. PMID 16541075.
Chaipan C, Soilleux EJ, Simpson P, et al. (2006). "DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets.". J. Virol. 80 (18): 8951–60. doi:10.1128/JVI.00136-06. PMID 16940507.
Watson AA, Brown J, Harlos K, et al. (2007). "The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2.". J. Biol. Chem. 282 (5): 3165–72. doi:10.1074/jbc.M610383200. PMID 17132623.
Suzuki-Inoue K, Kato Y, Inoue O, et al. (2007). "Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells.". J. Biol. Chem. 282 (36): 25993–6001. doi:10.1074/jbc.M702327200. PMID 17616532.