CLEC11A

From Wikipedia, the free encyclopedia

C-type lectin domain family 11, member A

Identifiers

CLEC11A; P47; CLECSF3; LSLCL; SCGF

External IDs

OMIM: 604713 MGI: 1298219 HomoloGene: 2236

Gene ontology
Molecular Function:	• sugar binding • growth factor activity
Cellular Component:	• extracellular region
Biological Process:	• positive regulation of cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002975 (mRNA)
NP_002966 (protein)

NM_009131 (mRNA)
NP_033157 (protein)

Location

Chr 19: 55.92 - 55.92 Mb

Chr 7: 44.17 - 44.17 Mb

Pubmed search

[1]

[2]

C-type lectin domain family 11, member A, also known as CLEC11A, is a human gene.^[1]

This gene encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice variant has been described but its biological nature has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: CLEC11A C-type lectin domain family 11, member A.

[edit] Further reading

Hiraoka A, Ohkubo T, Fukuda M (1987). "Production of human hematopoietic survival and growth factor by a myeloid leukemia cell line (KPB-M15) and placenta as detected by a monoclonal antibody.". Cancer Res. 47 (19): 5025-30. PMID 3304620.
Hiraoka A, Sugimura A, Seki T, et al. (1997). "Cloning, expression, and characterization of a cDNA encoding a novel human growth factor for primitive hematopoietic progenitor cells.". Proc. Natl. Acad. Sci. U.S.A. 94 (14): 7577-82. PMID 9207134.
Bannwarth S, Giordanengo V, Lesimple J, Lefebvre JC (1998). "Molecular cloning of a new secreted sulfated mucin-like protein with a C-type lectin domain that is expressed in lymphoblastic cells.". J. Biol. Chem. 273 (4): 1911-6. PMID 9442024.
Mio H, Kagami N, Yokokawa S, et al. (1998). "Isolation and characterization of a cDNA for human mouse, and rat full-length stem cell growth factor, a new member of C-type lectin superfamily.". Biochem. Biophys. Res. Commun. 249 (1): 124-30. doi:10.1006/bbrc.1998.9073. PMID 9705843.
Bannwarth S, Giordanengo V, Grosgeorge J, et al. (1999). "Cloning, mapping, and genomic organization of the LSLCL gene, encoding a new lymphocytic secreted mucin-like protein with a C-type lectin domain: A new model of exon shuffling.". Genomics 57 (2): 316-7. doi:10.1006/geno.1999.5762. PMID 10198175.
Gehling UM, Ergün S, Schumacher U, et al. (2000). "In vitro differentiation of endothelial cells from AC133-positive progenitor cells.". Blood 95 (10): 3106-12. PMID 10807776.
Perrin C, Bayle J, Bannwarth S, et al. (2002). "Expression of LSLCL, a new C-type lectin, is closely restricted, in bone marrow, to immature neutrophils.". C. R. Acad. Sci. III, Sci. Vie 324 (12): 1125-32. PMID 11803813.
Hiraoka A, Yano Ki K, Kagami N, et al. (2002). "Stem cell growth factor: in situ hybridization analysis on the gene expression, molecular characterization and in vitro proliferative activity of a recombinant preparation on primitive hematopoietic progenitor cells.". Hematol. J. 2 (5): 307-15. doi:10.1038/sj/thj/6200118. PMID 11920266.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ito C, Sato H, Ando K, et al. (2004). "Serum stem cell growth factor for monitoring hematopoietic recovery following stem cell transplantation.". Bone Marrow Transplant. 32 (4): 391-8. doi:10.1038/sj.bmt.1704152. PMID 12900775.
Lee E, Min HK, Oskeritzian CA, et al. (2004). "Recombinant human (rh) stem cell factor and rhIL-4 stimulate differentiation and proliferation of CD3+ cells from umbilical cord blood and CD3+ cells enhance FcepsilonR1 expression on fetal liver-derived mast cells in the presence of rhIL-4.". Cell. Immunol. 226 (1): 30-6. PMID 14746805.
Hollenbeck ST, Sakakibara K, Faries PL, et al. (2004). "Stem cell factor and c-kit are expressed by and may affect vascular SMCs through an autocrine pathway.". J. Surg. Res. 120 (2): 288-94. doi:10.1016/j.jss.2004.01.005. PMID 15234225.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.