CLDN6

From Wikipedia, the free encyclopedia

Claudin 6

Identifiers

External IDs

Gene ontology
Molecular Function:	• structural molecule activity • identical protein binding
Cellular Component:	• plasma membrane • tight junction • integral to membrane
Biological Process:	• calcium-independent cell-cell adhesion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_021195 (mRNA)
NP_067018 (protein)

NM_018777 (mRNA)
NP_061247 (protein)

Location

Chr 16: 3 - 3.01 Mb

Chr 17: 23.41 - 23.41 Mb

Pubmed search

[1]

[2]

Claudin 6, also known as CLDN6, is a human gene.^[1] It belongs to the group of claudins.

[edit] References

^ Entrez Gene: CLDN6 claudin 6.

[edit] Further reading

Kniesel U, Wolburg H (2000). "Tight junctions of the blood-brain barrier.". Cell. Mol. Neurobiol. 20 (1): 57–76. PMID 10690502.
Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport.". Traffic 2 (2): 93–8. PMID 11247307.
Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions.". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726.
Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets.". Curr. Opin. Cell Biol. 14 (5): 531–6. PMID 12231346.
González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins.". Prog. Biophys. Mol. Biol. 81 (1): 1–44. PMID 12475568.
Morita K, Furuse M, Fujimoto K, Tsukita S (1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands.". Proc. Natl. Acad. Sci. U.S.A. 96 (2): 511–6. PMID 9892664.
Morita K, Sasaki H, Furuse M, Tsukita S (1999). "Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells.". J. Cell Biol. 147 (1): 185–94. PMID 10508865.
Itoh M, Furuse M, Morita K, et al. (2000). "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins.". J. Cell Biol. 147 (6): 1351–63. PMID 10601346.
Turksen K, Troy TC (2001). "Claudin-6: a novel tight junction molecule is developmentally regulated in mouse embryonic epithelium.". Dev. Dyn. 222 (2): 292–300. doi:10.1002/dvdy.1174. PMID 11668606.
Kiuchi-Saishin Y, Gotoh S, Furuse M, et al. (2002). "Differential expression patterns of claudins, tight junction membrane proteins, in mouse nephron segments.". J. Am. Soc. Nephrol. 13 (4): 875–86. PMID 11912246.
Turksen K, Troy TC (2002). "Permeability barrier dysfunction in transgenic mice overexpressing claudin 6.". Development 129 (7): 1775–84. PMID 11923212.
Morita K, Furuse M, Yoshida Y, et al. (2002). "Molecular architecture of tight junctions of periderm differs from that of the maculae occludentes of epidermis.". J. Invest. Dermatol. 118 (6): 1073–9. doi:10.1046/j.1523-1747.2002.01774.x. PMID 12060405.
Reyes JL, Lamas M, Martin D, et al. (2003). "The renal segmental distribution of claudins changes with development.". Kidney Int. 62 (2): 476–87. doi:10.1046/j.1523-1755.2002.00479.x. PMID 12110008.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Katoh M, Katoh M (2004). "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family.". Int. J. Mol. Med. 11 (6): 683–9. PMID 12736707.