CLDN19

From Wikipedia, the free encyclopedia

Claudin 19

Identifiers

External IDs

OMIM: 610036 MGI: 3033992 HomoloGene: 17528

Gene ontology
Molecular Function:	• structural molecule activity • identical protein binding
Cellular Component:	• tight junction • membrane • integral to membrane
Biological Process:	• calcium-independent cell-cell adhesion • action potential propagation • apical junction assembly

Orthologs

Human

Mouse

Refseq

NM_148960 (mRNA)
NP_683763 (protein)

NM_001038590 (mRNA)
NP_001033679 (protein)

Location

Chr 1: 42.97 - 42.98 Mb

Chr 4: 118.75 - 118.76 Mb

Pubmed search

[1]

[2]

Claudin 19, also known as CLDN19, is a human gene.^[1] It belongs to the group of claudins.

Claudins, such as CLDN19, are transmembrane proteins found at tight junctions. Tight junctions form barriers that control the passage of ions and molecules across an epithelial sheet and the movement of proteins and lipids between apical and basolateral domains of epithelial cells (Lee et al., 2006).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: CLDN19 claudin 19.

[edit] Further reading

Kniesel U, Wolburg H (2000). "Tight junctions of the blood-brain barrier.". Cell. Mol. Neurobiol. 20 (1): 57-76. PMID 10690502.
Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport.". Traffic 2 (2): 93-8. PMID 11247307.
Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions.". Nat. Rev. Mol. Cell Biol. 2 (4): 285-93. doi:10.1038/35067088. PMID 11283726.
Tsukita S, Furuse M (2003). "Claudin-based barrier in simple and stratified cellular sheets.". Curr. Opin. Cell Biol. 14 (5): 531-6. PMID 12231346.
González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins.". Prog. Biophys. Mol. Biol. 81 (1): 1-44. PMID 12475568.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Lee NP, Tong MK, Leung PP, et al. (2006). "Kidney claudin-19: localization in distal tubules and collecting ducts and dysregulation in polycystic renal disease.". FEBS Lett. 580 (3): 923-31. doi:10.1016/j.febslet.2006.01.019. PMID 16427635.
Konrad M, Schaller A, Seelow D, et al. (2006). "Mutations in the tight-junction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvement.". Am. J. Hum. Genet. 79 (5): 949-57. doi:10.1086/508617. PMID 17033971.