CLCA1

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Chloride channel, calcium activated, family member 1
Identifiers
Symbol(s) CLCA1; CaCC
External IDs OMIM: 603906 MGI: 1346342 HomoloGene: 984
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 1179 23844
Ensembl ENSG00000016490 ENSMUSG00000028255
Refseq NM_001285 (mRNA)
NP_001276 (protein)		 XM_978159 (mRNA)
XP_983253 (protein)
Location Chr 1: 86.71 - 86.74 Mb Chr 3: 144.94 - 144.97 Mb
Pubmed search [1] [2]

Chloride channel, calcium activated, family member 1, also known as CLCA1, is a human gene.[1]

This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.[1]

[edit] References

  1. ^ a b Entrez Gene: CLCA1 chloride channel, calcium activated, family member 1.

[edit] Further reading

  • Hume JR, Duan D, Collier ML, et al. (2000). "Anion transport in heart.". Physiol. Rev. 80 (1): 31–81. PMID 10617765. 
  • Pauli BU, Abdel-Ghany M, Cheng HC, et al. (2001). "Molecular characteristics and functional diversity of CLCA family members.". Clin. Exp. Pharmacol. Physiol. 27 (11): 901–5. PMID 11071307. 
  • Gruber AD, Elble RC, Ji HL, et al. (1999). "Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl- channel proteins.". Genomics 54 (2): 200–14. doi:10.1006/geno.1998.5562. PMID 9828122. 
  • Agnel M, Vermat T, Culouscou JM (1999). "Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea.". FEBS Lett. 455 (3): 295–301. PMID 10437792. 
  • Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800. 
  • Liu QH, Williams DA, McManus C, et al. (2000). "HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation.". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. doi:10.1073/pnas.090521697. PMID 10758170. 
  • Toda M, Tulic MK, Levitt RC, Hamid Q (2002). "A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma.". J. Allergy Clin. Immunol. 109 (2): 246–50. PMID 11842292. 
  • Greenwood IA, Miller LJ, Ohya S, Horowitz B (2002). "The large conductance potassium channel beta-subunit can interact with and modulate the functional properties of a calcium-activated chloride channel, CLCA1.". J. Biol. Chem. 277 (25): 22119–22. doi:10.1074/jbc.C200215200. PMID 11994272. 
  • Abdel-Ghany M, Cheng HC, Elble RC, Pauli BU (2002). "Focal adhesion kinase activated by beta(4) integrin ligation to mCLCA1 mediates early metastatic growth.". J. Biol. Chem. 277 (37): 34391–400. doi:10.1074/jbc.M205307200. PMID 12110680. 
  • Loewen ME, Bekar LK, Gabriel SE, et al. (2002). "pCLCA1 becomes a cAMP-dependent chloride conductance mediator in Caco-2 cells.". Biochem. Biophys. Res. Commun. 298 (4): 531–6. PMID 12408984. 
  • Zhou Y, Shapiro M, Dong Q, et al. (2003). "A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction.". Novartis Found. Symp. 248: 150–65; discussion 165–70, 277–82. PMID 12568493. 
  • Abdel-Ghany M, Cheng HC, Elble RC, et al. (2004). "The interacting binding domains of the beta(4) integrin and calcium-activated chloride channels (CLCAs) in metastasis.". J. Biol. Chem. 278 (49): 49406–16. doi:10.1074/jbc.M309086200. PMID 14512419. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Hegab AE, Sakamoto T, Uchida Y, et al. (2004). "CLCA1 gene polymorphisms in chronic obstructive pulmonary disease.". J. Med. Genet. 41 (3): e27. PMID 14985398. 
  • Kamada F, Suzuki Y, Shao C, et al. (2005). "Association of the hCLCA1 gene with childhood and adult asthma.". Genes Immun. 5 (7): 540–7. doi:10.1038/sj.gene.6364124. PMID 15318163. 
  • Ritzka M, Stanke F, Jansen S, et al. (2005). "The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis.". Hum. Genet. 115 (6): 483–91. doi:10.1007/s00439-004-1190-y. PMID 15490240. 
  • Gibson A, Lewis AP, Affleck K, et al. (2005). "hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels.". J. Biol. Chem. 280 (29): 27205–12. doi:10.1074/jbc.M504654200. PMID 15919655. 
  • Jeong SM, Park HK, Yoon IS, et al. (2005). "Cloning and expression of Ca2+-activated chloride channel from rat brain.". Biochem. Biophys. Res. Commun. 334 (2): 569–76. doi:10.1016/j.bbrc.2005.06.122. PMID 16023076. 
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