CLASP2

From Wikipedia, the free encyclopedia

Cytoplasmic linker associated protein 2

Identifiers

External IDs

OMIM: 605853 MGI: 1923749 HomoloGene: 24944

Gene ontology
Molecular Function:	• binding • protein binding • galactoside 2-alpha-L-fucosyltransferase activity • microtubule plus-end binding
Cellular Component:	• cytoplasm • Golgi apparatus • kinetochore microtubule • cytoskeleton • cytoplasmic microtubule
Biological Process:	• negative regulation of microtubule depolymerization • cell cycle • mitosis • establishment and/or maintenance of cell polarity • regulation of microtubule polymerization or depolymerization • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015097 (mRNA)
NP_055912 (protein)

NM_001081960 (mRNA)
NP_001075429 (protein)

Location

Chr 3: 33.51 - 33.73 Mb

Chr 9: 113.59 - 113.77 Mb

Pubmed search

[1]

[2]

Cytoplasmic linker associated protein 2, also known as CLASP2, is a human gene.^[1]

[edit] References

^ Entrez Gene: CLASP2 cytoplasmic linker associated protein 2.

[edit] Further reading

Galjart N (2005). "CLIPs and CLASPs and cellular dynamics.". Nat. Rev. Mol. Cell Biol. 6 (6): 487-98. doi:10.1038/nrm1664. PMID 15928712.
Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169-76. PMID 9734811.
Lemos CL, Sampaio P, Maiato H, et al. (2000). "Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization.". EMBO J. 19 (14): 3668-82. doi:10.1093/emboj/19.14.3668. PMID 10899121.
Akhmanova A, Hoogenraad CC, Drabek K, et al. (2001). "Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts.". Cell 104 (6): 923-35. PMID 11290329.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Maiato H, Fairley EA, Rieder CL, et al. (2003). "Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics.". Cell 113 (7): 891-904. PMID 12837247.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Lee H, Engel U, Rusch J, et al. (2004). "The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance.". Neuron 42 (6): 913-26. doi:10.1016/j.neuron.2004.05.020. PMID 15207236.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Mimori-Kiyosue Y, Grigoriev I, Lansbergen G, et al. (2005). "CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex.". J. Cell Biol. 168 (1): 141-53. doi:10.1083/jcb.200405094. PMID 15631994.
Wittmann T, Waterman-Storer CM (2005). "Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cells.". J. Cell Biol. 169 (6): 929-39. doi:10.1083/jcb.200412114. PMID 15955847.
Lansbergen G, Grigoriev I, Mimori-Kiyosue Y, et al. (2006). "CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta.". Dev. Cell 11 (1): 21-32. doi:10.1016/j.devcel.2006.05.012. PMID 16824950.
Mimori-Kiyosue Y, Grigoriev I, Sasaki H, et al. (2006). "Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment.". Genes Cells 11 (8): 845-57. doi:10.1111/j.1365-2443.2006.00990.x. PMID 16866869.
Pereira AL, Pereira AJ, Maia AR, et al. (2007). "Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function.". Mol. Biol. Cell 17 (10): 4526-42. doi:10.1091/mbc.E06-07-0579. PMID 16914514.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.