CLASP1

From Wikipedia, the free encyclopedia

Cytoplasmic linker associated protein 1

Identifiers

CLASP1; MAST1; DKFZp686D1968; DKFZp686H2039; FLJ33821; FLJ41222; KIAA0622; MGC131895

External IDs

OMIM: 605852 MGI: 1923957 HomoloGene: 41024

Gene ontology
Molecular Function:	• protein binding • kinetochore binding • microtubule plus-end binding
Cellular Component:	• kinetochore • Golgi apparatus • centrosome • kinetochore microtubule • cytoskeleton • cytoplasmic microtubule • cortical microtubule cytoskeleton
Biological Process:	• microtubule bundle formation • negative regulation of microtubule depolymerization • cell cycle • mitosis • establishment and/or maintenance of cell polarity • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015282 (mRNA)
NP_056097 (protein)

XM_884205 (mRNA)
XP_889298 (protein)

Location

Chr 2: 121.81 - 122.12 Mb

Chr 1: 120.22 - 120.44 Mb

Pubmed search

[1]

[2]

Cytoplasmic linker associated protein 1, also known as CLASP1, is a human gene.^[1]

CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: CLASP1 cytoplasmic linker associated protein 1.

[edit] Further reading

Galjart N (2005). "CLIPs and CLASPs and cellular dynamics.". Nat. Rev. Mol. Cell Biol. 6 (6): 487–98. doi:10.1038/nrm1664. PMID 15928712.
Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (3): 169–76. PMID 9734811.
Lemos CL, Sampaio P, Maiato H, et al. (2000). "Mast, a conserved microtubule-associated protein required for bipolar mitotic spindle organization.". EMBO J. 19 (14): 3668–82. doi:10.1093/emboj/19.14.3668. PMID 10899121.
Akhmanova A, Hoogenraad CC, Drabek K, et al. (2001). "Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts.". Cell 104 (6): 923–35. PMID 11290329.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Maiato H, Fairley EA, Rieder CL, et al. (2003). "Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics.". Cell 113 (7): 891–904. PMID 12837247.
Maiato H, Rieder CL, Earnshaw WC, Sunkel CE (2004). "How do kinetochores CLASP dynamic microtubules?". Cell Cycle 2 (6): 511–4. PMID 14504462.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Mimori-Kiyosue Y, Grigoriev I, Lansbergen G, et al. (2005). "CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex.". J. Cell Biol. 168 (1): 141–53. doi:10.1083/jcb.200405094. PMID 15631994.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Venables JP, Bourgeois CF, Dalgliesh C, et al. (2005). "Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon.". Hum. Mol. Genet. 14 (16): 2289–303. doi:10.1093/hmg/ddi233. PMID 16000324.
Aonuma M, Miyamoto M, Inoue YH, et al. (2006). "Microtubule bundle formation and cell death induced by the human CLASP/Orbit N-terminal fragment.". Cell Struct. Funct. 30 (1): 7–13. PMID 16145243.
Lansbergen G, Grigoriev I, Mimori-Kiyosue Y, et al. (2006). "CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta.". Dev. Cell 11 (1): 21–32. doi:10.1016/j.devcel.2006.05.012. PMID 16824950.
Mimori-Kiyosue Y, Grigoriev I, Sasaki H, et al. (2006). "Mammalian CLASPs are required for mitotic spindle organization and kinetochore alignment.". Genes Cells 11 (8): 845–57. doi:10.1111/j.1365-2443.2006.00990.x. PMID 16866869.
Pereira AL, Pereira AJ, Maia AR, et al. (2007). "Mammalian CLASP1 and CLASP2 cooperate to ensure mitotic fidelity by regulating spindle and kinetochore function.". Mol. Biol. Cell 17 (10): 4526–42. doi:10.1091/mbc.E06-07-0579. PMID 16914514.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.