CKS2

From Wikipedia, the free encyclopedia

CDC28 protein kinase regulatory subunit 2

PDB rendering based on 1cks.

Available structures: 1cks

Identifiers

Symbol(s)

CKS2; CKSHS2

External IDs

OMIM: 116901 MGI: 1913447 HomoloGene: 86883

Gene ontology
Molecular Function:	• cyclin-dependent protein kinase regulator activity
Biological Process:	• regulation of cyclin-dependent protein kinase activity • cell cycle • spindle organization and biogenesis • meiosis I • cell proliferation • phosphoinositide-mediated signaling • cell division

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_001827 (mRNA)
NP_001818 (protein)

NM_025415 (mRNA)
NP_079691 (protein)

Location

Chr 9: 91.12 - 91.12 Mb

n/a

Pubmed search

[1]

[2]

CDC28 protein kinase regulatory subunit 2, also known as CKS2, is a human gene.^[1]

CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein.^[1]

[edit] References

^ ^a ^b Entrez Gene: CKS2 CDC28 protein kinase regulatory subunit 2.

[edit] Further reading

Richardson HE, Stueland CS, Thomas J, et al. (1990). "Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe.". Genes Dev. 4 (8): 1332–44. PMID 2227411.
Parge HE, Arvai AS, Murtari DJ, et al. (1993). "Human CksHs2 atomic structure: a role for its hexameric assembly in cell cycle control.". Science 262 (5132): 387–95. PMID 8211159.
Demetrick DJ, Zhang H, Beach DH (1996). "Chromosomal mapping of the human genes CKS1 to 8q21 and CKS2 to 9q22.". Cytogenet. Cell Genet. 73 (3): 250–4. PMID 8697818.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Le XF, Lammayot A, Gold D, et al. (2005). "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling.". J. Biol. Chem. 280 (3): 2092–104. doi:10.1074/jbc.M403080200. PMID 15504738.
Gorr IH, Boos D, Stemmann O (2005). "Mutual inhibition of separase and Cdk1 by two-step complex formation.". Mol. Cell 19 (1): 135–41. doi:10.1016/j.molcel.2005.05.022. PMID 15989971.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Rother K, Dengl M, Lorenz J, et al. (2007). "Gene expression of cyclin-dependent kinase subunit Cks2 is repressed by the tumor suppressor p53 but not by the related proteins p63 or p73.". FEBS Lett. 581 (6): 1166–72. doi:10.1016/j.febslet.2007.02.028. PMID 17336302.
Bertheau P, Turpin E, Rickman DS, et al. (2007). "Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen.". PLoS Med. 4 (3): e90. doi:10.1371/journal.pmed.0040090. PMID 17388661.