CKS1B

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CDC28 protein kinase regulatory subunit 1B
PDB rendering based on 1buh.
Available structures: 1buh, 1dks, 1dkt, 2ass, 2ast
Identifiers
Symbol(s) CKS1B; CKS1; PNAS-16; PNAS-18; ckshs1
External IDs OMIM: 116900 MGI: 1889208 HomoloGene: 1380
Orthologs
Human Mouse
Entrez 1163 54124
Ensembl n/a ENSMUSG00000028044
Uniprot n/a Q9D0L3
Refseq NM_001826 (mRNA)
NP_001817 (protein)		 NM_016904 (mRNA)
NP_058600 (protein)
Location n/a Chr 3: 89.5 - 89.5 Mb
Pubmed search [1] [2]

CDC28 protein kinase regulatory subunit 1B, also known as CKS1B, is a human gene.[1]

CKS1B protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS1B mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects a specialized role for the encoded protein.[1]

[edit] References

  1. ^ a b Entrez Gene: CKS1B CDC28 protein kinase regulatory subunit 1B.

[edit] Further reading

  • Richardson HE, Stueland CS, Thomas J, et al. (1990). "Human cDNAs encoding homologs of the small p34Cdc28/Cdc2-associated protein of Saccharomyces cerevisiae and Schizosaccharomyces pombe.". Genes Dev. 4 (8): 1332–44. PMID 2227411. 
  • Arvai AS, Bourne Y, Hickey MJ, Tainer JA (1995). "Crystal structure of the human cell cycle protein CksHs1: single domain fold with similarity to kinase N-lobe domain.". J. Mol. Biol. 249 (5): 835–42. doi:10.1006/jmbi.1995.0341. PMID 7791211. 
  • Bourne Y, Watson MH, Hickey MJ, et al. (1996). "Crystal structure and mutational analysis of the human CDK2 kinase complex with cell cycle-regulatory protein CksHs1.". Cell 84 (6): 863–74. PMID 8601310. 
  • Demetrick DJ, Zhang H, Beach DH (1996). "Chromosomal mapping of the human genes CKS1 to 8q21 and CKS2 to 9q22.". Cytogenet. Cell Genet. 73 (3): 250–4. PMID 8697818. 
  • Ganoth D, Bornstein G, Ko TK, et al. (2001). "The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27.". Nat. Cell Biol. 3 (3): 321–4. doi:10.1038/35060126. PMID 11231585. 
  • Sitry D, Seeliger MA, Ko TK, et al. (2003). "Three different binding sites of Cks1 are required for p27-ubiquitin ligation.". J. Biol. Chem. 277 (44): 42233–40. doi:10.1074/jbc.M205254200. PMID 12140288. 
  • Seeliger MA, Breward SE, Itzhaki LS (2003). "Weak cooperativity in the core causes a switch in folding mechanism between two proteins of the cks family.". J. Mol. Biol. 325 (1): 189–99. PMID 12473461. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Xu K, Belunis C, Chu W, et al. (2003). "Protein-protein interactions involved in the recognition of p27 by E3 ubiquitin ligase.". Biochem. J. 371 (Pt 3): 957–64. doi:10.1042/BJ20021722. PMID 12529174. 
  • Wang W, Ungermannova D, Chen L, Liu X (2003). "A negatively charged amino acid in Skp2 is required for Skp2-Cks1 interaction and ubiquitination of p27Kip1.". J. Biol. Chem. 278 (34): 32390–6. doi:10.1074/jbc.M305241200. PMID 12813041. 
  • Bashir T, Dorrello NV, Amador V, et al. (2004). "Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C(Cdh1) ubiquitin ligase.". Nature 428 (6979): 190–3. doi:10.1038/nature02330. PMID 15014502. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Kitajima S, Kudo Y, Ogawa I, et al. (2005). "Role of Cks1 overexpression in oral squamous cell carcinomas: cooperation with Skp2 in promoting p27 degradation.". Am. J. Pathol. 165 (6): 2147–55. PMID 15579456. 
  • Seeliger MA, Spichty M, Kelly SE, et al. (2005). "Role of conformational heterogeneity in domain swapping and adapter function of the Cks proteins.". J. Biol. Chem. 280 (34): 30448–59. doi:10.1074/jbc.M501450200. PMID 15772084. 
  • Slotky M, Shapira M, Ben-Izhak O, et al. (2006). "The expression of the ubiquitin ligase subunit Cks1 in human breast cancer.". Breast Cancer Res. 7 (5): R737–44. doi:10.1186/bcr1278. PMID 16168119. 
  • Shaughnessy J (2006). "Amplification and overexpression of CKS1B at chromosome band 1q21 is associated with reduced levels of p27Kip1 and an aggressive clinical course in multiple myeloma.". Hematology 10 Suppl 1: 117–26. doi:10.1080/10245330512331390140. PMID 16188652. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Hao B, Zheng N, Schulman BA, et al. (2005). "Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase.". Mol. Cell 20 (1): 9–19. doi:10.1016/j.molcel.2005.09.003. PMID 16209941. 
  • Bhatt KV, Hu R, Spofford LS, Aplin AE (2007). "Mutant B-RAF signaling and cyclin D1 regulate Cks1/S-phase kinase-associated protein 2-mediated degradation of p27Kip1 in human melanoma cells.". Oncogene 26 (7): 1056–66. doi:10.1038/sj.onc.1209861. PMID 16924241. 
  • Yao ZP, Zhou M, Kelly SE, et al. (2006). "Activation of ubiquitin ligase SCF(Skp2) by Cks1: insights from hydrogen exchange mass spectrometry.". J. Mol. Biol. 363 (3): 673–86. doi:10.1016/j.jmb.2006.08.032. PMID 16979657. 
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