CKLF (gene)

From Wikipedia, the free encyclopedia

Chemokine-like factor

Identifiers

CKLF; C32; CKLF1; CKLF2; CKLF3; CKLF4; HSPC224; UCK-1

External IDs

MGI: 1922708 HomoloGene: 9663

Gene ontology
Molecular Function:	• chemokine activity
Cellular Component:	• extracellular region • extracellular space • membrane • integral to membrane
Biological Process:	• chemotaxis • cell proliferation • neutrophil chemotaxis • secretory pathway • macrophage chemotaxis • lymphocyte chemotaxis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001040138 (mRNA)
NP_001035228 (protein)

NM_001037840 (mRNA)
NP_001032929 (protein)

Location

Chr 16: 65.14 - 65.16 Mb

Chr 8: 107.14 - 107.15 Mb

Pubmed search

[1]

[2]

Chemokine-like factor, also known as CKLF, is a human gene.^[1]

The product of this gene is a cytokine. Cytokines are small proteins that have an essential role in the immune and inflammatory responses. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. The protein encoded by this gene is a potent chemoattractant for neutrophils, monocytes and lymphocytes. It also can stimulate the proliferation of skeletal muscle cells. This protein may play important roles in inflammation and in the regeneration of skeletal muscle. Alternatively spliced transcript variants encoding different isoforms have been identified.^[1]

[edit] References

^ ^a ^b Entrez Gene: CKLF chemokine-like factor.

[edit] Further reading

Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546-60. PMID 11042152.
Han W, Lou Y, Tang J, et al. (2001). "Molecular cloning and characterization of chemokine-like factor 1 (CKLF1), a novel human cytokine with unique structure and potential chemotactic activity.". Biochem. J. 357 (Pt 1): 127-35. PMID 11415443.
Boudinot P, Salhi S, Blanco M, Benmansour A (2002). "Viral haemorrhagic septicaemia virus induces vig-2, a new interferon-responsive gene in rainbow trout.". Fish Shellfish Immunol. 11 (5): 383-97. doi:10.1006/fsim.2000.0326. PMID 11478515.
Xia D, Li X, Lou Y, et al. (2002). "Overexpression of chemokine-like factor 2 promotes the proliferation and survival of C2C12 skeletal muscle cells.". Biochim. Biophys. Acta 1591 (1-3): 163-173. PMID 12183067.
Ke X, Jia L, Jing H, et al. (2002). "Effects of novel human chemokine-like factor 1 (CKLF1) on bone marrow hematopoietic stem cell/progenitor cell in vitro.". Zhonghua Xue Ye Xue Za Zhi 23 (6): 301-3. PMID 12411060.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Xu M, Han W, Qian M, et al. (2004). "Last intron of the chemokine-like factor gene contains a putative promoter for the downstream CKLF super family member 1 gene.". Biochem. Biophys. Res. Commun. 313 (1): 135-41. PMID 14672709.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.