CKAP5

From Wikipedia, the free encyclopedia

Cytoskeleton associated protein 5

Identifiers

CKAP5; FLJ35359; KIAA0097; TOG; TOGp; ch-TOG

External IDs

MGI: 1923036 HomoloGene: 8844

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• gamma-tubulin complex • centrosome
Biological Process:	• establishment and/or maintenance of microtubule cytoskeleton polarity • RNA transport • centrosome organization and biogenesis • spindle pole body organization and biogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001008938 (mRNA)
NP_001008938 (protein)

NM_029437 (mRNA)
NP_083713 (protein)

Location

Chr 11: 46.72 - 46.82 Mb

Chr 2: 91.33 - 91.42 Mb

Pubmed search

[1]

[2]

Cytoskeleton associated protein 5, also known as CKAP5, is a human gene.^[1]

[edit] References

^ Entrez Gene: CKAP5 cytoskeleton associated protein 5.

[edit] Further reading

Basto R, Gergely F, Draviam VM, et al. (2007). "Hsp90 is required to localise cyclin B and Msps/ch-TOG to the mitotic spindle in Drosophila and humans.". J. Cell. Sci. 120 (Pt 7): 1278–87. doi:10.1242/jcs.000604. PMID 17376965.
Kosturko LD, Maggipinto MJ, D'Sa C, et al. (2005). "The microtubule-associated protein tumor overexpressed gene binds to the RNA trafficking protein heterogeneous nuclear ribonucleoprotein A2.". Mol. Biol. Cell 16 (4): 1938–47. doi:10.1091/mbc.E04-08-0709. PMID 15703215.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Cassimeris L, Morabito J (2004). "TOGp, the human homolog of XMAP215/Dis1, is required for centrosome integrity, spindle pole organization, and bipolar spindle assembly.". Mol. Biol. Cell 15 (4): 1580–90. doi:10.1091/mbc.E03-07-0544. PMID 14718566.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Conte N, Delaval B, Ginestier C, et al. (2003). "TACC1-chTOG-Aurora A protein complex in breast cancer.". Oncogene 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID 14603251.
Gergely F, Draviam VM, Raff JW (2003). "The ch-TOG/XMAP215 protein is essential for spindle pole organization in human somatic cells.". Genes Dev. 17 (3): 336–41. doi:10.1101/gad.245603. PMID 12569123.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMID 12421765.
Lauffart B, Howell SJ, Tasch JE, et al. (2002). "Interaction of the transforming acidic coiled-coil 1 (TACC1) protein with ch-TOG and GAS41/NuBI1 suggests multiple TACC1-containing protein complexes in human cells.". Biochem. J. 363 (Pt 1): 195–200. PMID 11903063.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Charrasse S, Mazel M, Taviaux S, et al. (1996). "Characterization of the cDNA and pattern of expression of a new gene over-expressed in human hepatomas and colonic tumors.". Eur. J. Biochem. 234 (2): 406–13. PMID 8536682.
Nagase T, Miyajima N, Tanaka A, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (1): 37–43. PMID 7788527.