Citrate (Re)-synthase

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In enzymology, a citrate (Re)-synthase (EC 2.3.3.3) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + H₂O + oxaloacetate $\rightleftharpoons$ citrate + CoA

The 3 substrates of this enzyme are acetyl-CoA, H₂O, and oxaloacetate, whereas its two products are citrate and CoA.

This enzyme belongs to the family of transferases, specifically those acyltransferases that convert acyl groups into alkyl groups on transfer. The systematic name of this enzyme class is acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-R)-carboxymethyl-forming]. Other names in common use include (R)-citrate synthase, Re-citrate-synthase, and citrate oxaloacetate-lyase [(pro-3R)-CH2COO-->acetyl-CoA].

[edit] References

IUBMB entry for 2.3.3.3
BRENDA references for 2.3.3.3 (Recommended.)
PubMed references for 2.3.3.3
PubMed Central references for 2.3.3.3
Google Scholar references for 2.3.3.3
Dittbrenner S, Chowdhury AA, Gottschalk G (1969). "The stereospecificity of the (R)-citrates synthase in the presence of p-chloromercuribenzoate". Biochem. Biophys. Res. Commun. 36: 802–8. doi:10.1016/0006-291X(69)90680-9. PMID 5808294.
Gottschalk G (1969). "Partial purification and some properties of the (R)-citrate synthase from Clostridium acidi-urici". Eur. J. Biochem. 7: 301–6. doi:10.1111/j.1432-1033.1969.tb19607.x. PMID 4974734.
Gottschalk G, Barker HA (1966). "Synthesis of glutamate and citrate by Clostridium kluyveri. A new type of citrate synthase". Biochemistry. 5: 1125–33. doi:10.1021/bi00868a003. PMID 5958189.