Cis-2-enoyl-CoA reductase (NADPH)

From Wikipedia, the free encyclopedia

In enzymology, a cis-2-enoyl-CoA reductase (NADPH) (EC 1.3.1.37) is an enzyme that catalyzes the chemical reaction

acyl-CoA + NADP⁺ cis-2,3-dehydroacyl-CoA + NADPH + H⁺

Thus, the two substrates of this enzyme are acyl-CoA and NADP⁺, whereas its 3 products are cis-2,3-dehydroacyl-CoA, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is acyl-CoA:NADP+ cis-2-oxidoreductase. Other names in common use include NADPH-dependent cis-enoyl-CoA reductase, reductase, cis-2-enoyl coenzyme A, cis-2-enoyl-coenzyme A reductase, and cis-2-enoyl-CoA reductase (NADPH).

[edit] References

• IUBMB entry for 1.3.1.37
• BRENDA references for 1.3.1.37 (Recommended.)
• PubMed references for 1.3.1.37
• PubMed Central references for 1.3.1.37
• Google Scholar references for 1.3.1.37
• H (Tokyo). "Studies on the metabolism of unsaturated fatty acids. IX Stereochemical studies of the reaction catalyzed by trans-2-enoyl-coenzyme A reductase of Escherichia coli". J. Biochem.: 1649–54. PMID 6759504. 

[edit] External links

The CAS registry number for this enzyme class is 72841-00-0.

• IUBMB entry for 1.3.1.37

• KEGG entry for 1.3.1.37

• BRENDA entry for 1.3.1.37

• NiceZyme view of 1.3.1.37

• EC2PDB: PDB structures for 1.3.1.37

• PRIAM entry for 1.3.1.37

• PUMA2 entry for 1.3.1.37

• IntEnz: Integrated Enzyme entry for 1.3.1.37

• MetaCyc entry for 1.3.1.37

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047774: cis-2-enoyl-CoA reductase (NADPH)

• AMIGO entry for GO code 0047774: cis-2-enoyl-CoA reductase (NADPH)