Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
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In enzymology, a cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase (EC 1.3.1.56) is an enzyme that catalyzes the chemical reaction
- cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+ biphenyl-2,3-diol + NADH + H+
Thus, the two substrates of this enzyme are cis-3-phenylcyclohexa-3,5-diene-1,2-diol and NAD+, whereas its 3 products are biphenyl-2,3-diol, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cis-3-phenylcyclohexa-3,5-diene-1,2-diol:NAD+ oxidoreductase. This enzyme is also called 2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase. This enzyme participates in biphenyl degradation.
[edit] References
- IUBMB entry for 1.3.1.56
- BRENDA references for 1.3.1.56 (Recommended.)
- PubMed references for 1.3.1.56
- PubMed Central references for 1.3.1.56
- Google Scholar references for 1.3.1.56
- Sylvestre M, Hurtubise Y, Barriault D, Bergeron J, Ahmad D (1996). "Characterization of active recombinant 2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase from Comamonas testosteroni B-356 and sequence of the encoding gene (bphB)". Appl. Environ. Microbiol. 62: 2710–5. PMID 8702262.
- Takagi M, Yano K (1994). "Identification of the bphA and bphB genes of Pseudomonas sp. strains KKS102 involved in degradation of biphenyl and polychlorinated biphenyls". Biochem. Biophys. Res. Commun. 202: 850–6. doi: . PMID 8048958.
- Hofer B, Eltis LD, Dowling DN, Timmis KN (1993). "Genetic analysis of a Pseudomonas locus encoding a pathway for biphenyl/polychlorinated biphenyl degradation". Gene. 130: 47–55. doi: . PMID 8344527.