Cis-1,2-dihydrobenzene-1,2-diol dehydrogenase

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In enzymology, a cis-1,2-dihydrobenzene-1,2-diol dehydrogenase (EC 1.3.1.19) is an enzyme that catalyzes the chemical reaction

cis-1,2-dihydrobenzene-1,2-diol + NAD⁺ $\rightleftharpoons$ catechol + NADH + H⁺

Thus, the two substrates of this enzyme are cis-1,2-dihydrobenzene-1,2-diol and NAD⁺, whereas its 3 products are catechol, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cis-1,2-dihydrobenzene-1,2-diol:NAD+ oxidoreductase. Other names in common use include cis-benzene glycol dehydrogenase, cis-1,2-dihydrocyclohexa-3,5-diene (nicotinamide adenine, and dinucleotide) oxidoreductase. This enzyme participates in 4 metabolic pathways: gamma-hexachlorocyclohexane degradation, toluene and xylene degradation, naphthalene and anthracene degradation, and styrene degradation.

[edit] References

IUBMB entry for 1.3.1.19
BRENDA references for 1.3.1.19 (Recommended.)
PubMed references for 1.3.1.19
PubMed Central references for 1.3.1.19
Google Scholar references for 1.3.1.19
Axcell BC, Geary PJ (1973). "The metabolism of benzene by bacteria. Purification and some properties of the enzyme cis-1,2-dihydroxycyclohexa-3,5-diene (nicotinamide adenine dinucleotide) oxidoreductase (cis-benzene glycol dehydrogenase)". Biochem. J. 136: 927–34. PMID 4362337.
Gibson DT, Koch JR, Kallio RE (1968). "Oxidative degradation of aromatic hydrocarbons by microorganisms. I Enzymatic formation of catechol from benzene". Biochemistry. 7: 2653–62. doi:10.1021/bi00847a031. PMID 4298226.