Cinchocaine


Cinchocaine
Systematic (IUPAC) name
2-butoxy-N-(2-diethylaminoethyl) quinoline-4-carboxamide
Identifiers
CAS number	85-79-0
ATC code	C05AD04 D04 AB02 N01 BB06 S01 HA06
PubChem	3025
DrugBank	APRD00915
Chemical data
Formula	C₂₀H₂₉N₃O₂
Mol. mass	343.463 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	topical, intravenous (equine euthanasia)

Cinchocaine (or Dibucaine) is an amide local anesthetic. It is the active ingredient in some topical hemorrhoid creams.

It is also a component of the veterinary drug Somulose, used for euthanasia of horses and cattle.

[edit] External links

Abdel-Ghani N, Youssef A, Awady M (2005). "Cinchocaine hydrochloride determination by atomic absorption spectrometry and spectrophotometry.". Farmaco 60 (5): 419–24. doi:10.1016/j.farmac.2005.03.001. PMID 15910814.
Souto-Padron T, Lima AP, de Oliveira Ribeiro R. (2006). "Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi.". Parasitol Res. doi:10.1007/s00436-006-0192-1. PMID 16612626.
Nounou M, El-Khordagui L, Khalafallah N. "Effect of various formulation variables on the encapsulation and stability of dibucaine base in multilamellar vesicles.". Acta Pol Pharm 62 (5): 369–79. PMID 16459486.

v • d • e Vasoprotectives (C05)

Antihemorrhoidals for topical use	corticosteroids (Hydrocortisone, Prednisolone, Betamethasone, Fluorometholone, Fluocortolone, Dexamethasone, Fluocinolone acetonide, Fluocinonide) - local anesthetics (Lidocaine, Tetracaine, Benzocaine, Cinchocaine, Procaine, Oxetacaine, Pramocaine) - other (Tribenoside)

Antivaricose therapy	heparins or heparinoids for topical use (Organo-heparinoid, Sodium apolate, Heparin, Pentosan polysulfate) sclerosing agents for local injection (Monoethanolamine oleate, Polidocanol, Invert sugar, Sodium tetradecyl sulfate, Phenol) other (Calcium dobesilate)

Capillary stabilising agents	bioflavonoids (Rutoside, Monoxerutin, Diosmin, Troxerutin, Hidrosmin) - other (Tribenoside)

v • d • e Antipruritics (D04)

Antihistamines for topical use	Thonzylamine - Mepyramine - Thenalidine - Tripelennamine - Chloropyramine - Promethazine - Tolpropamine - Dimetindene - Clemastine - Bamipine - Isothipendyl - Diphenhydramine - Chlorphenoxamine

Anesthetics for topical use	Lidocaine - Cinchocaine - Oxybuprocaine - Benzocaine - Quinisocaine - Tetracaine - Pramocaine

v • d • e Anesthetics: Local anesthetics (N01B)

Esters of aminobenzoic acid	Amylocaine, Benzocaine, Butacaine, Chloroprocaine, Dimethocaine, Meprylcaine, Metabutozycaine, Orthocaine, Propoxycaine, Procaine, Proparacaine, Risocaine, Tetracaine

Amides	Articaine, Bupivacaine, Carticaine, Cinchocaine, Etidocaine, Levobupivacaine, Lidocaine, Mepivacaine, Prilocaine, Ropivacaine, Trimecaine

Esters of benzoic acid	Cocaine, Piperocaine

Other	Hexylcaine, Iontocaine, Lidocaine/prilocaine