CIB1

From Wikipedia, the free encyclopedia

Calcium and integrin binding 1 (calmyrin)

PDB rendering based on 1dgu.

Available structures: 1dgu, 1dgv, 1xo5, 1y1a

Identifiers

Symbol(s)

CIB1; CALMYRIN; CIB; KIP; SIP2-28

External IDs

OMIM: 602293 MGI: 1344418 HomoloGene: 4654

Gene ontology
Molecular Function:	• calcium ion binding • protein binding
Cellular Component:	• nucleoplasm • cytoplasm • endoplasmic reticulum • membrane
Biological Process:	• double-strand break repair • apoptosis • response to DNA damage stimulus • cell adhesion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006384 (mRNA)
NP_006375 (protein)

NM_011870 (mRNA)
NP_036000 (protein)

Location

Chr 15: 88.57 - 88.58 Mb

Chr 7: 80.1 - 80.11 Mb

Pubmed search

[1]

[2]

Calcium and integrin binding 1 (calmyrin), also known as CIB1, is a human gene.^[1]

The protein encoded by this gene is a member of the calcium-binding protein family. The specific function of this protein has not yet been determined; however this protein is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end joining. This protein also interacts with integrin alpha(IIb)beta(3), which may implicate this protein as a regulatory molecule for alpha(IIb)beta(3).^[1]

[edit] References

^ ^a ^b Entrez Gene: CIB1 calcium and integrin binding 1 (calmyrin).

[edit] Further reading

Naik UP, Patel PM, Parise LV (1997). "Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain.". J. Biol. Chem. 272 (8): 4651-4. PMID 9030514.
Wu X, Lieber MR (1997). "Interaction between DNA-dependent protein kinase and a novel protein, KIP.". Mutat. Res. 385 (1): 13-20. PMID 9372844.
Seki N, Hayashi A, Abe M, et al. (1999). "Chromosomal assignment of the gene for human DNA-PKcs interacting protein (KIP) on chromosome 15q25.3-q26.1 by somatic hybrid analysis and fluorescence in situ hybridization.". J. Hum. Genet. 43 (4): 275-7. PMID 9852683.
Stabler SM, Ostrowski LL, Janicki SM, Monteiro MJ (1999). "A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein.". J. Cell Biol. 145 (6): 1277-92. PMID 10366599.
Kauselmann G, Weiler M, Wulff P, et al. (1999). "The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity.". EMBO J. 18 (20): 5528-39. doi:10.1093/emboj/18.20.5528. PMID 10523297.
Hwang PM, Vogel HJ (2000). "Structures of the platelet calcium- and integrin-binding protein and the alphaIIb-integrin cytoplasmic domain suggest a mechanism for calcium-regulated recognition; homology modelling and NMR studies.". J. Mol. Recognit. 13 (2): 83-92. doi:10.1002/(SICI)1099-1352(200003/04)13:2<83::AID-JMR491>3.0.CO;2-A. PMID 10822252.
Hattori A, Seki N, Hayashi A, et al. (2000). "Genomic structure of mouse and human genes for DNA-PKcs interacting protein (KIP).". DNA Seq. 10 (6): 415-8. PMID 10826701.
Holtrich U, Wolf G, Yuan J, et al. (2000). "Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages.". Oncogene 19 (42): 4832-9. doi:10.1038/sj.onc.1203845. PMID 11039900.
Haataja L, Kaartinen V, Groffen J, Heisterkamp N (2002). "The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading.". J. Biol. Chem. 277 (10): 8321-8. doi:10.1074/jbc.M105363200. PMID 11756406.
Whitehouse C, Chambers J, Howe K, et al. (2002). "NBR1 interacts with fasciculation and elongation protein zeta-1 (FEZ1) and calcium and integrin binding protein (CIB) and shows developmentally restricted expression in the neural tube.". Eur. J. Biochem. 269 (2): 538-45. PMID 11856312.
Hollenbach AD, McPherson CJ, Lagutina I, Grosveld G (2002). "The EF-hand calcium-binding protein calmyrin inhibits the transcriptional and DNA-binding activity of Pax3.". Biochim. Biophys. Acta 1574 (3): 321-8. PMID 11997098.
Henderson MJ, Russell AJ, Hird S, et al. (2002). "EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response.". J. Biol. Chem. 277 (29): 26468-78. doi:10.1074/jbc.M203527200. PMID 12011095.
Barry WT, Boudignon-Proudhon C, Shock DD, et al. (2002). "Molecular basis of CIB binding to the integrin alpha IIb cytoplasmic domain.". J. Biol. Chem. 277 (32): 28877-83. doi:10.1074/jbc.M202983200. PMID 12023286.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ma S, Liu MA, Yuan YL, Erikson RL (2003). "The serum-inducible protein kinase Snk is a G1 phase polo-like kinase that is inhibited by the calcium- and integrin-binding protein CIB.". Mol. Cancer Res. 1 (5): 376-84. PMID 12651910.
Naik UP, Naik MU (2003). "Association of CIB with GPIIb/IIIa during outside-in signaling is required for platelet spreading on fibrinogen.". Blood 102 (4): 1355-62. doi:10.1182/blood-2003-02-0591. PMID 12714504.
Naik MU, Naik UP (2004). "Calcium-and integrin-binding protein regulates focal adhesion kinase activity during platelet spreading on immobilized fibrinogen.". Blood 102 (10): 3629-36. doi:10.1182/blood-2003-05-1703. PMID 12881299.
Yamniuk AP, Nguyen LT, Hoang TT, Vogel HJ (2004). "Metal ion binding properties and conformational states of calcium- and integrin-binding protein.". Biochemistry 43 (9): 2558-68. doi:10.1021/bi035432b. PMID 14992593.
Lee GE, Yu EY, Cho CH, et al. (2004). "DNA-protein kinase catalytic subunit-interacting protein KIP binds telomerase by interacting with human telomerase reverse transcriptase.". J. Biol. Chem. 279 (33): 34750-5. doi:10.1074/jbc.M401843200. PMID 15190070.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315-23. doi:10.1101/gr.2122004. PMID 15231747.