CHSY1

From Wikipedia, the free encyclopedia

Carbohydrate (chondroitin) synthase 1

Identifiers

CHSY1; KIAA0990

External IDs

OMIM: 608183 MGI: 2681120 HomoloGene: 8950

Gene ontology
Molecular Function:	• transferase activity • metal ion binding • glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity • N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity
Cellular Component:	• membrane • integral to membrane

Orthologs

Human

Mouse

Entrez

22856

269941

Refseq

NM_014918 (mRNA)
NP_055733 (protein)

XM_194358 (mRNA)
XP_194358 (protein)

Pubmed search

[1]

[2]

Carbohydrate (chondroitin) synthase 1, also known as CHSY1, is a human gene.^[1]

CHSY1 synthesizes chondroitin sulfate, a glycosaminoglycan expressed on the surface of most cells and in extracellular matrices. Glycosaminoglycan chains are covalently linked to a wide range of core protein families and regulate many biologic processes, including cell proliferation and recognition, extracellular matrix deposition, and morphogenesis.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: CHSY1 carbohydrate (chondroitin) synthase 1.

[edit] Further reading

Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Yada T, Sato T, Kaseyama H, et al. (2003). "Chondroitin sulfate synthase-3. Molecular cloning and characterization.". J. Biol. Chem. 278 (41): 39711–25. doi:10.1074/jbc.M304421200. PMID 12907687.
Kitagawa H, Izumikawa T, Uyama T, Sugahara K (2003). "Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization.". J. Biol. Chem. 278 (26): 23666–71. doi:10.1074/jbc.M302493200. PMID 12716890.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Kitagawa H, Uyama T, Sugahara K (2001). "Molecular cloning and expression of a human chondroitin synthase.". J. Biol. Chem. 276 (42): 38721–6. doi:10.1074/jbc.M106871200. PMID 11514575.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (1): 63–70. PMID 10231032.