CHST5

From Wikipedia, the free encyclopedia

Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5

Identifiers

CHST5; FLJ22167; I-GlcNAc-6-ST; MGC74625

External IDs

Gene ontology
Molecular Function:	• N-acetylglucosamine 6-O-sulfotransferase activity • transferase activity
Cellular Component:	• Golgi apparatus • membrane • integral to membrane • intrinsic to Golgi membrane
Biological Process:	• carbohydrate metabolic process • N-acetylglucosamine metabolic process • protein amino acid sulfation • sulfur metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

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Refseq

NM_012126 (mRNA)
NP_036258 (protein)

n/a (mRNA)
n/a (protein)

Location

Chr 16: 74.12 - 74.13 Mb

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Pubmed search

[1]

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Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5, also known as CHST5, is a human gene.^[1]

[edit] References

^ Entrez Gene: CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5.

[edit] Further reading

Bernstein HB, Compans RW (1992). "Sulfation of the human immunodeficiency virus envelope glycoprotein.". J. Virol. 66 (12): 6953–9. PMID 1433500.
Shilatifard A, Merkle RK, Helland DE, et al. (1993). "Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine.". J. Virol. 67 (2): 943–52. PMID 8419650.
Lee JK, Bhakta S, Rosen SD, Hemmerich S (1999). "Cloning and characterization of a mammalian N-acetylglucosamine-6-sulfotransferase that is highly restricted to intestinal tissue.". Biochem. Biophys. Res. Commun. 263 (2): 543–9. doi:10.1006/bbrc.1999.1324. PMID 10491328.
Akama TO, Nishida K, Nakayama J, et al. (2000). "Macular corneal dystrophy type I and type II are caused by distinct mutations in a new sulphotransferase gene.". Nat. Genet. 26 (2): 237–41. doi:10.1038/79987. PMID 11017086.
Bartes A, Bhakta S, Hemmerich S (2001). "Sulfation of endothelial mucin by corneal keratan N-acetylglucosamine 6-O-sulfotransferase (GST-4beta).". Biochem. Biophys. Res. Commun. 282 (4): 928–33. doi:10.1006/bbrc.2001.4668. PMID 11352640.
Seko A, Nagata K, Yonezawa S, Yamashita K (2003). "Ectopic expression of a GlcNAc 6-O-sulfotransferase, GlcNAc6ST-2, in colonic mucinous adenocarcinoma.". Glycobiology 12 (6): 379–88. PMID 12107080.
Akama TO, Misra AK, Hindsgaul O, Fukuda MN (2003). "Enzymatic synthesis in vitro of the disulfated disaccharide unit of corneal keratan sulfate.". J. Biol. Chem. 277 (45): 42505–13. doi:10.1074/jbc.M207412200. PMID 12218059.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Lee JK, Bistrup A, van Zante A, Rosen SD (2004). "Activities and expression pattern of the carbohydrate sulfotransferase GlcNAc6ST-3 (I-GlcNAc6ST): functional implications.". Glycobiology 13 (4): 245–54. doi:10.1093/glycob/cwg018. PMID 12626414.
de Graffenried CL, Bertozzi CR (2003). "Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis.". J. Biol. Chem. 278 (41): 40282–95. doi:10.1074/jbc.M304928200. PMID 12855678.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kitayama K, Hayashida Y, Nishida K, Akama TO (2007). "Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans.". J. Biol. Chem. 282 (41): 30085–96. doi:10.1074/jbc.M703695200. PMID 17690104.