CHST2

From Wikipedia, the free encyclopedia

Carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2

Identifiers

External IDs

OMIM: 603798 MGI: 1891160 HomoloGene: 3150

Gene ontology
Molecular Function:	• N-acetylglucosamine 6-O-sulfotransferase activity • transferase activity
Cellular Component:	• trans-Golgi network • membrane • integral to membrane • intrinsic to Golgi membrane
Biological Process:	• carbohydrate metabolic process • N-acetylglucosamine metabolic process • sulfur metabolic process • inflammatory response • multicellular organismal development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_004267 (mRNA)
NP_004258 (protein)

NM_018763 (mRNA)
NP_061233 (protein)

Location

Chr 3: 144.32 - 144.32 Mb

Chr 9: 95.21 - 95.22 Mb

Pubmed search

[1]

[2]

Carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2, also known as CHST2, is a human gene.^[1]

[edit] References

^ Entrez Gene: CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2.

[edit] Further reading

Bernstein HB, Compans RW (1992). "Sulfation of the human immunodeficiency virus envelope glycoprotein.". J. Virol. 66 (12): 6953–9. PMID 1433500.
Shilatifard A, Merkle RK, Helland DE, et al. (1993). "Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine.". J. Virol. 67 (2): 943–52. PMID 8419650.
Uchimura K, Muramatsu H, Kadomatsu K, et al. (1998). "Molecular cloning and characterization of an N-acetylglucosamine-6-O-sulfotransferase.". J. Biol. Chem. 273 (35): 22577–83. PMID 9712885.
Uchimura K, Muramatsu H, Kaname T, et al. (1998). "Human N-acetylglucosamine-6-O-sulfotransferase involved in the biosynthesis of 6-sulfo sialyl Lewis X: molecular cloning, chromosomal mapping, and expression in various organs and tumor cells.". J. Biochem. 124 (3): 670–8. PMID 9722682.
Li X, Tedder TF (1999). "CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization.". Genomics 55 (3): 345–7. doi:10.1006/geno.1998.5653. PMID 10049591.
Tu L, Murphy PG, Li X, Tedder TF (1999). "L-selectin ligands expressed by human leukocytes are HECA-452 antibody-defined carbohydrate epitopes preferentially displayed by P-selectin glycoprotein ligand-1.". J. Immunol. 163 (9): 5070–8. PMID 10528213.
Sakaguchi H, Kitagawa H, Sugahara K (2000). "Functional expression and genomic structure of human N-acetylglucosamine-6-O-sulfotransferase that transfers sulfate to beta-N-acetylglucosamine at the nonreducing end of an N-acetyllactosamine sequence.". Biochim. Biophys. Acta 1523 (2-3): 269–76. PMID 11042394.
Okuda T, Mita S, Yamauchi S, et al. (2001). "Molecular cloning, expression, and chromosomal mapping of human chondroitin 4-sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-sulfotransferase.". J. Biochem. 128 (5): 763–70. PMID 11056388.
Li X, Tu L, Murphy PG, et al. (2001). "CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin.". J. Leukoc. Biol. 69 (4): 565–74. PMID 11310842.
Uchimura K, El-Fasakhany FM, Hori M, et al. (2002). "Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression.". J. Biol. Chem. 277 (6): 3979–84. doi:10.1074/jbc.M106587200. PMID 11726653.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Grunwell JR, Rath VL, Rasmussen J, et al. (2003). "Characterization and mutagenesis of Gal/GlcNAc-6-O-sulfotransferases.". Biochemistry 41 (52): 15590–600. PMID 12501187.
de Graffenried CL, Bertozzi CR (2003). "Golgi localization of carbohydrate sulfotransferases is a determinant of L-selectin ligand biosynthesis.". J. Biol. Chem. 278 (41): 40282–95. doi:10.1074/jbc.M304928200. PMID 12855678.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
de Graffenried CL, Bertozzi CR (2004). "The stem region of the sulfotransferase GlcNAc6ST-1 is a determinant of substrate specificity.". J. Biol. Chem. 279 (38): 40035–43. doi:10.1074/jbc.M405709200. PMID 15220337.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Chen L, Ichihara-Tanaka K, Muramatsu T (2005). "Role of the carboxyl-terminal region in the activity of N-acetylglucosamine 6-o-sulfotransferase-1.". J. Biochem. 136 (5): 659–64. doi:10.1093/jb/mvh162. PMID 15632306.
Kanoh A, Seko A, Ideo H, et al. (2007). "Ectopic expression of N-acetylglucosamine 6-O-sulfotransferase 2 in chemotherapy-resistant ovarian adenocarcinomas.". Glycoconj. J. 23 (5-6): 453–60. doi:10.1007/s10719-006-6979-6. PMID 16897186.