CHST1

From Wikipedia, the free encyclopedia

Carbohydrate (keratan sulfate Gal-6) sulfotransferase 1

Identifiers

CHST1; C6ST; KS6ST; KSGal6ST

External IDs

OMIM: 603797 MGI: 1924219 HomoloGene: 2711

Gene ontology
Molecular Function:	• transferase activity • keratan sulfotransferase activity
Cellular Component:	• membrane • integral to membrane • intrinsic to Golgi membrane
Biological Process:	• polysaccharide metabolic process • galactose metabolic process • inflammatory response • keratan sulfate metabolic process

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003654 (mRNA)
NP_003645 (protein)

NM_023850 (mRNA)
NP_076339 (protein)

Location

Chr 11: 45.63 - 45.64 Mb

Chr 2: 92.41 - 92.42 Mb

Pubmed search

[1]

[2]

Carbohydrate (keratan sulfate Gal-6) sulfotransferase 1, also known as CHST1, is a human gene.^[1]

[edit] References

^ Entrez Gene: CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1.

[edit] Further reading

Williams KJ (1997). "Atherosclerosis: cell biology and lipoproteins.". Curr. Opin. Lipidol. 7 (6): U202–8. PMID 9117134.
Bernstein HB, Compans RW (1992). "Sulfation of the human immunodeficiency virus envelope glycoprotein.". J. Virol. 66 (12): 6953–9. PMID 1433500.
Shilatifard A, Merkle RK, Helland DE, et al. (1993). "Complex-type N-linked oligosaccharides of gp120 from human immunodeficiency virus type 1 contain sulfated N-acetylglucosamine.". J. Virol. 67 (2): 943–52. PMID 8419650.
Fukuta M, Inazawa J, Torii T, et al. (1998). "Molecular cloning and characterization of human keratan sulfate Gal-6-sulfotransferase.". J. Biol. Chem. 272 (51): 32321–8. PMID 9405439.
Mazany KD, Peng T, Watson CE, et al. (1998). "Human chondroitin 6-sulfotransferase: cloning, gene structure, and chromosomal localization.". Biochim. Biophys. Acta 1407 (1): 92–7. PMID 9639683.
Li X, Tedder TF (1999). "CHST1 and CHST2 sulfotransferases expressed by human vascular endothelial cells: cDNA cloning, expression, and chromosomal localization.". Genomics 55 (3): 345–7. doi:10.1006/geno.1998.5653. PMID 10049591.
Bistrup A, Bhakta S, Lee JK, et al. (1999). "Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin.". J. Cell Biol. 145 (4): 899–910. PMID 10330415.
Tu L, Murphy PG, Li X, Tedder TF (1999). "L-selectin ligands expressed by human leukocytes are HECA-452 antibody-defined carbohydrate epitopes preferentially displayed by P-selectin glycoprotein ligand-1.". J. Immunol. 163 (9): 5070–8. PMID 10528213.
Torii T, Fukuta M, Habuchi O (2000). "Sulfation of sialyl N-acetyllactosamine oligosaccharides and fetuin oligosaccharides by keratan sulfate Gal-6-sulfotransferase.". Glycobiology 10 (2): 203–11. PMID 10642612.
Li X, Tu L, Murphy PG, et al. (2001). "CHST1 and CHST2 sulfotransferase expression by vascular endothelial cells regulates shear-resistant leukocyte rolling via L-selectin.". J. Leukoc. Biol. 69 (4): 565–74. PMID 11310842.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Yamada T, Ohtake S, Sato M, Habuchi O (2005). "Chondroitin 4-sulphotransferase-1 and chondroitin 6-sulphotransferase-1 are affected differently by uronic acid residues neighbouring the acceptor GalNAc residues.". Biochem. J. 384 (Pt 3): 567–75. doi:10.1042/BJ20040965. PMID 15324304.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Liu J, Chau CH, Liu H, et al. (2006). "Upregulation of chondroitin 6-sulphotransferase-1 facilitates Schwann cell migration during axonal growth.". J. Cell. Sci. 119 (Pt 5): 933–42. doi:10.1242/jcs.02796. PMID 16495484.
Kitayama K, Hayashida Y, Nishida K, Akama TO (2007). "Enzymes responsible for synthesis of corneal keratan sulfate glycosaminoglycans.". J. Biol. Chem. 282 (41): 30085–96. doi:10.1074/jbc.M703695200. PMID 17690104.