Talk:Chronic granulomatous disease

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	Chronic granulomatous disease has been listed as one of the Natural sciences good articles under the good article criteria. If you can improve it further, please do. If it no longer meets these criteria, you can delist it, or ask for a reassessment.
September 28, 2006 Good article nominee Listed

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To-do:	edit · history · watch · refresh
Strike through when completed Picture for infobox Infobox External links Reference for NBT See WP:MEDMOS for suggestions on layout and style

Contents 1 older entries 2 Comments 3 Re: Suggestions 4 Good article nomination 4.1 GA awarded 5 phagocyte NADPH oxidase - or NADPH oxidase complex containing several PHOX'es?

[edit] older entries

Expanced article...please contact me with any suggestions, questions, or comments.--Jfurr1981 04:14, 16 September 2006 (UTC)

[edit] Comments

The following sentence could be reworded for clarity:

• X-linked Chronic Granulomatous disease: defect in membrane NADPH oxidase. Autosomal Recessive Chronic Granulomatous disease: defect in cytoplasmic NADPH oxidase.

In the news article it says that 3 people were recruited to the gene therapy trial, the article says 2. --apers0n 15:22, 16 September 2006 (UTC)

For first read:

• no external links
• a reference for NBT would be useful
• "X-linked Chronic Granulomatous disease: defect in membrane NADPH oxidase. Autosomal Recessive Chronic Granulomatous disease: defect in cytoplasmic NADPH oxidase." sentence should written ina better prose sytle.

NCurse _work 15:36, 16 September 2006 (UTC)

[edit] Re: Suggestions

Reworked the genetics and therapy (specifically gene therapy) sections, added external links and an infobox, and added a reference for the NBT test. Thanks for the input AspersOn and NCurse.Jfurr1981 13:25, 17 September 2006 (UTC)

[edit] Good article nomination

My suggestions:

• "CGD affects about 1 in 200,000 people in the United States, with at least 20 new cases diagnosed each year." (a reference would be useful)

  Fixed.

• section Genetics: Image:X-link dominant father.jpg, Image:XlinkRecessive.jpg, Image:Xlink dominant mother.jpg?

  Added pictures.

• "A low level of NADPH, the cofactor required for superoxide synthesis, can lead to CGD. This has been reported in women who are homozygous for the genetic defect causing glucose-6-phosphate dehydrogenase deficiency (G6PD), which is characterised by reduced NADPH levels." (reference?)

  Can't find source for the whole cite but both lines are mentioned throughout the literature.

• "Thus, CGD should be considered as a diagnosis in patients with an Aspergillus infection whose cause in unknown." (reference?)

  Removed.

• a cytochrome C reduction assay reference would be useful too

  Unnecessary, this part is understandable in its own.

Anyway great article! NCurse _work 17:20, 17 September 2006 (UTC)

[edit] GA awarded

After re-reviewing the article and adding the necessary stuff requested by NCurse, it compares with the GA criteria by passing all of them. It might not be a long article but it covers the most important topics for now. An expansion would still be of use but it is a good article after all. Lincher 02:29, 28 September 2006 (UTC)

Thanks for the help. :) NCurse _work 11:31, 28 September 2006 (UTC)

[edit] phagocyte NADPH oxidase - or NADPH oxidase complex containing several PHOX'es?

Phagocytes (i.e., neutrophils, monocytes, and macrophages) require an enzyme to produce reactive oxygen species to destroy bacteria after they ingest the bacteria in a process called phagocytosis. This enzyme is termed "phagocyte NADPH oxidase" (PHOX)

- I googled a little and find mentions of either NADPH oxidase complex or of phagocyte oxidase (PHOX) subinits of this complex. Maybe there's a little mistake here. Best regards, CopperKettle (talk) 13:54, 14 December 2007 (UTC)