Chromosome 6 (human)

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This article is about about a chromosome. For the novel of the same name, see Chromosome 6 (novel) .

Chromosome 6 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 6 spans more than 170 million base pairs (the building material of DNA) and represents between 5.5 and 6% of the total DNA in cells. It contains the Major Histocompatibility Complex, which contains over 100 genes related to the immune response, and plays a vital role in organ transplantation.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 6 likely contains between 1,100 and 1,600 genes.^{[citation needed]}

1 Genes
2 Diseases & disorders
3 References
4 Chromosome 6 in fiction

[edit] Genes

The following are some of the genes located on chromosome 6:

BCKDHB: branched chain keto acid dehydrogenase E1, beta polypeptide (maple syrup urine disease)
COL11A2: collagen, type XI, alpha 2
CYP21A2: cytochrome P450, family 21, subfamily A, polypeptide 2
DSP: Desmoplakin gene linked to cardiomyopathy
EYA4: eyes absent homolog 4 (Drosophila)
HFE: hemochromatosis
HLA-B: major histocompatibility complex, class I, B
MUT: methylmalonyl Coenzyme A mutase
MYO6: myosin VI
PARK2: Parkinson disease (autosomal recessive, juvenile) 2, parkin
PKHD1: polycystic kidney and hepatic disease 1 (autosomal recessive)
TNXB: tenascin XB
VEGF: vascular endothelial growth factor A (angiogenic growth factor)
IGF2R: insulin-like growth factor 2 receptor

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Further information might be found on the talk page or at requests for expansion.

[edit] Diseases & disorders

The following diseases are some of those related to genes on chromosome 6:

ankylosing spondylitis
collagenopathy, types II and XI
Ehlers-Danlos syndrome
Ehlers-Danlos syndrome, classical type
Ehlers-Danlos syndrome, hypermobility type
hemochromatosis
hemochromatosis, type 1
21-hydroxylase deficiency
maple syrup urine disease
methylmalonic acidemia
nonsyndromic deafness
nonsyndromic deafness, autosomal dominant
nonsyndromic deafness, autosomal recessive
otospondylomegaepiphyseal dysplasia
Parkinson disease
polycystic kidney disease
porphyria
porphyria cutanea tarda
Stickler syndrome, COL11A2
X-linked sideroblastic anemia
Epilepsy

[edit] References

Some text in this article was taken from http://ghr.nlm.nih.gov/chromosome=6 (public domain)
Gilbert F (2002). "Chromosome 6". Genet Test 6 (4): 341–58. doi:10.1089/10906570260199429. PMID 12537662.
Mungall AJ et alii (2003). "The DNA sequence and analysis of human chromosome 6". Nature 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.

[edit] Chromosome 6 in fiction

Further information: Chromosome 6 (novel)

Robin Cook's book, Chromosome 6, explores the possibility of transferring a little bit of human DNA onto very close relatives of the human, genetically wise, bonobos in this case, in order to create organs that would not be rejected by the human body. Chromosome six is mentioned because HLA-B, the major histocompatibility complex, class I, B is present.