Chromosome 14 (human)

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Chromosome 14 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 14 spans about 106 million base pairs (the building material of DNA) and represents between 3 and 3.5% of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated r of genes varies. Chromosome 14 likely contains between 700 and 1,300 genes.

[edit] Genes

The following are some of the genes located on chromosome 14:

COCH: coagulation factor C homolog, cochlin (Limulus polyphemus)
GALC: galactosylceramidase (Krabbe disease)
GCH1: GTP cyclohydrolase 1 (dopa-responsive dystonia)
IGH@: immunoglobulin heavy chain locus
NPC2: Niemann-Pick disease, type C2
PSEN1: presenilin 1 (Alzheimer disease 3)
SERPINA1: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
TSHR: thyroid stimulating hormone receptor

[edit] Diseases & disorders

The following diseases are some of those related to genes on chromosome 14:

alpha-1 antitrypsin deficiency
Alzheimer disease
Alzheimer disease, type 3
congenital hypothyroidism
Krabbe disease
multiple myeloma
Niemann-Pick disease
nonsyndromic deafness
nonsyndromic deafness, autosomal dominant
tetrahydrobiopterin deficiency

[edit] References

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