Christopher Voigt

From Wikipedia, the free encyclopedia

Christopher A. Voigt
Born Ann Arbor, Michigan
Citizenship U.S.
Nationality U.S.
Fields Synthetic Biology
Institutions University of California - San Francisco
Alma mater University of Michigan, California Institute of Technology, University of California - Berkeley
Doctoral advisor Zhen-Gang Wang, Francis Arnold, Stephen Mayo, Adam P Arkin

Christopher Voigt is an American synthetic biologist, molecular biophysicist, and engineer. He is currently an assistant Professor in the Pharmaceutical Chemistry department of the University of California - San Francisco with appointments in the Biophysics and the Chemistry and Chemical Biology graduate student programs. His research interests focus on the reprogramming of bacterial organisms to perform coordinated, complex tasks for pharmaceutical and industrial applications. He is a member of the National Science Foundation-funded Synthetic Biology Engineering Research Center, called SynBERC, and is a leader in the developing field of synthetic biology. His recent successes include:

  • Engineering a bacterial two-component system to regulate gene expression in response to red light.[1]
  • Engineering bacteria to sense its environment and conditionally invade cancer cells either when the concentration of bacteria is large enough, when the environment has little oxygen (e.g. inside a tumor), or when a specific chemical is present. [2]

Current research projects use these new environmental sensors and logical switches to control the assembly and function of newly redesigned systems, such as a secretion needle that exports spider silk proteins or a photosynthetic apparatus responsible for converting light into chemical energy. These redesigned (or refactored) systems can help us to tackle the important problems facing a 21st century world, including meeting the energy demand and finding new, stronger materials.

[edit] External links

Chris Voigt Research Lab Website

[edit] References

  1. ^ Levskaya A, Chevalier AA, Tabor JJ, Simpson ZB, Lavery LA, Levy M, Davidson EA, Scouras A, Ellington AD, Marcotte EM, Voigt CA (2005). "Synthetic biology: engineering Escherichia coli to see light". Nature 438 (7067): 441–2. doi:10.1038/nature04405. PMID 16306980. 
  2. ^ Anderson JC, Clarke EJ, Arkin AP, Voigt CA (2006). "Environmentally controlled invasion of cancer cells by engineered bacteria". J. Mol. Biol. 355 (4): 619–27. doi:10.1016/j.jmb.2005.10.076. PMID 16330045. 
  3. ^ Anderson JC, Voigt CA, Arkin AP (2007). "Environmental signal integration by a modular AND gate". Mol. Syst. Biol. 3: 133. doi:10.1038/msb4100173. PMID 17700541.