CHP (gene)

From Wikipedia, the free encyclopedia

Calcium binding protein P22

PDB rendering based on 2ct9.

Available structures: 2ct9, 2e30

Identifiers

Symbol(s)

CHP; SLC9A1BP

External IDs

OMIM: 606988 MGI: 1927185 HomoloGene: 5235

Gene ontology
Molecular Function:	• calcium ion binding • potassium channel regulator activity
Biological Process:	• potassium ion transport • small GTPase mediated signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_007236 (mRNA)
NP_009167 (protein)

XM_001002884 (mRNA)
XP_001002884 (protein)

Location

Chr 15: 39.31 - 39.36 Mb

n/a

Pubmed search

[1]

[2]

Calcium binding protein P22, also known as CHP, is a human gene.^[1]

The protein encoded by this gene is a phosphoprotein that binds to the sodium-potassium exchangers (NHEs). This protein serves as an essential cofactor which supports the physiological activity of NHE family members. It has protein sequence similarity to calcineurin B and it is also known to be an endogenous inhibitor of calcineurin activity.^[1]

[edit] References

^ ^a ^b Entrez Gene: CHP calcium binding protein P22.

[edit] Further reading

Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics 23 (1): 42-50. doi:10.1006/geno.1994.1457. PMID 7829101.
Barroso MR, Bernd KK, DeWitt ND, et al. (1996). "A novel Ca2+-binding protein, p22, is required for constitutive membrane traffic.". J. Biol. Chem. 271 (17): 10183-7. PMID 8626580.
Lin X, Barber DL (1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange.". Proc. Natl. Acad. Sci. U.S.A. 93 (22): 12631-6. PMID 8901634.
Lin X, Sikkink RA, Rusnak F, Barber DL (2000). "Inhibition of calcineurin phosphatase activity by a calcineurin B homologous protein.". J. Biol. Chem. 274 (51): 36125-31. PMID 10593895.
Pang T, Su X, Wakabayashi S, Shigekawa M (2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers.". J. Biol. Chem. 276 (20): 17367-72. doi:10.1074/jbc.M100296200. PMID 11350981.
Matsumoto M, Miyake Y, Nagita M, et al. (2001). "A serine/threonine kinase which causes apoptosis-like cell death interacts with a calcineurin B-like protein capable of binding Na(+)/H(+) exchanger.". J. Biochem. 130 (2): 217-25. PMID 11481038.
Nakamura N, Miyake Y, Matsushita M, et al. (2003). "KIF1Bbeta2, capable of interacting with CHP, is localized to synaptic vesicles.". J. Biochem. 132 (3): 483-91. PMID 12204119.
Pang T, Wakabayashi S, Shigekawa M (2003). "Expression of calcineurin B homologous protein 2 protects serum deprivation-induced cell death by serum-independent activation of Na+/H+ exchanger.". J. Biol. Chem. 277 (46): 43771-7. doi:10.1074/jbc.M208313200. PMID 12226101.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Inoue H, Nakamura Y, Nagita M, et al. (2003). "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium.". Biol. Pharm. Bull. 26 (2): 148-55. PMID 12576672.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Pang T, Hisamitsu T, Mori H, et al. (2004). "Role of calcineurin B homologous protein in pH regulation by the Na+/H+ exchanger 1: tightly bound Ca2+ ions as important structural elements.". Biochemistry 43 (12): 3628-36. doi:10.1021/bi0360004. PMID 15035633.
Andrade J, Pearce ST, Zhao H, Barroso M (2005). "Interactions among p22, glyceraldehyde-3-phosphate dehydrogenase and microtubules.". Biochem. J. 384 (Pt 2): 327-36. doi:10.1042/BJ20040622. PMID 15312048.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Ben Ammar Y, Takeda S, Sugawara M, et al. (2006). "Crystallization and preliminary crystallographic analysis of the human calcineurin homologous protein CHP2 bound to the cytoplasmic region of the Na+/H+ exchanger NHE1.". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 61 (Pt 10): 956-8. doi:10.1107/S1744309105030836. PMID 16511206.
Mishima M, Wakabayashi S, Kojima C (2007). "Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1.". J. Biol. Chem. 282 (4): 2741-51. doi:10.1074/jbc.M604092200. PMID 17050540.