Talk:Choline
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Article Grading: The following comments were left by the quality and importance raters: (edit · history · watch · refresh) According to an article in the New England Journal of Medicine, individuals with depression and manic-depressive disorder appear to be hypersensitive to the neurotransmitter acetylcholine. Therefore, choline should not be taken in a dose that exceeds the amount in a multiple vitamin. Avoid Choline and the amino acids ornithine and afginine. These substances may make symptoms of Manic Depression/depression worse. |
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Article Grading: The following comments were left by the quality and importance raters: (edit · history · refresh · how to use this template) According to an article in the New England Journal of Medicine, individuals with depression and manic-depressive disorder appear to be hypersensitive to the neurotransmitter acetylcholine. Therefore, choline should not be taken in a dose that exceeds the amount in a multiple vitamin. Avoid Choline and the amino acids ornithine and afginine. These substances may make symptoms of Manic Depression/depression worse. |
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[edit] Wikiprojects update
I have updated the information from the Chemicals and Molecular and Cellular Biology Wikiprojects above (although I am unable to access the full version of the paper online and marked that a full citation is needed). I have also removed a recent edit that cited the impermeability of Choline to the Blood-Brain barrier as it seemed at odds with the information from the NEJM (which suggests that choline supplements can have a direct effect on the brain) and did not cite its sources (perhaps OR?).SupernautRemix 14:59, 11 June 2007 (UTC)
[edit] Acetylcholine
The neurotransmitter acetylcholine is converted into choline and acetic acid by the enzyme acetylcholinesterase.
- Isn't choline converted into acetylcholine? Crusadeonilliteracy 13:14, 16 Feb 2004 (UTC)
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- Acetylcholine is built from its components within neurons, but once released into the synaptic cleft it is digested by the esterase so that the signal it is relaying is stopped quickly. Both (catabolic and anabolic) processes are happening continually.
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- On a different topic: The chemical formula on this page isn't very helpful in discerning structure. In fact, it has confused the hell out of me. Anyone got a diagram?
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- Here's a trick – type 'choline' into images.google.com. It gave me this right away. You've got three methyls and a C2H4OH all bound to N+. It's ionicly bound to X– where X can be OH or anything else that forms a negative ion. Anybody want to take a crack at a better diagram? David.Throop 00:29, 15 February 2006 (UTC)
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[edit] Pharmaceutical uses
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Please help improve this article or section by expanding it. Further information might be found on the talk page or at requests for expansion. (January 2007) |
I notice a lot of health stores and online pharmacies are selling choline tablets. Perhaps someone with the requisite knowledge could add to this article an explanation of what it's used for. —Psychonaut 14:21, 14 February 2006 (UTC)
[edit] Reply to Pharmaceutical uses
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Please help improve this article or section by expanding it. Further information might be found on the talk page or at requests for expansion. (January 2007) |
Using choline as a supplement is (by now) supported by some human studies, where choline deficiency associates with birth deffects. However, ther are not enough human studies to really demonstrate that choline supplementation could really solve this problem, nor if over-supplementation is clean of any side-effects (as it happens for instance with Vitamin A). User:Mdnic 15 May 2006
I'd heard that Choline mobilises fat deposits and this is why it is in health supplements. Haven't got a reference though...
- Choline is also used a lot as a 'smart drug', because of the central role that acetylcholine plays in a lot of cognitive systems. I've added a reference to this to the article, but my neuropsychology isn't too hot these days (never was to be honest) so I can't give as many details as this would merit. There's a lot of info out there if anyone is inclined to sift through it... User:SupernautRemix 62.6.249.131 15:28, 22 January 2007 (UTC)
- "Eggs are rich in choline, which your body uses to produce the
neurotransmitter acetylcholine. Researchers at Boston University found that when healthy young adults were given the drug scopolamine, which blocks acetylcholine receptors in the brain, it significantly reduced their ability to remember word pairs. Low levels of acetylcholine are also associated with Alzheimer's disease, and some studies suggest that boosting dietary intake may slow age-related memory loss."
- from http://www.newscientist.com/channel/being-human/mg18625011.900
One wonders whether the upswing in Alzheimer's is due to all of those folks watching their cholesterol and avoiding too many eggs. 210.50.176.52 00:48, 1 June 2007 (UTC) Ian Ison
[edit] Choline as an essential nutrient
To all authors on Choline,
I have just erased the introductory phrase. Choline is not essential for cardiovascular
function (if so, please send me the reference). Acetylcholine is essential for neuronal and neuro-muscular transmission of the impulse, but this is covered by another article. —The preceding unsigned comment was added by Mdnic (talk • contribs) 23:54, 27 March 2007 (UTC).
[edit] New England Journal of Medicine "citation needed"
I searched PubMed for the New England Journal of Medicine article about choline (the one with citation needed), and I found a 1979 article titled "Choline and lecithin in the treatment of neurological disorders." It's so old that there's no full-text online. http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=431620&ordinalpos=39&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
So, at this point, I can't confirm or deny that statement about choline possibly exacerbating depression. Derekawesome 19:58, 22 October 2007 (UTC)
[edit] Invented By Whom?
Hello. Didn't Charles Best discover choline as what Britannica says? Thanks. --Mayfare 05:00, 3 December 2007 (UTC)
