Choroid plexus cyst
From Wikipedia, the free encyclopedia
| Choroid plexus cyst Classification and external resources |
|
| ICD-10 | G93.0 |
|---|---|
| ICD-9 | 348.0 |
Choroid plexus cysts (CPCs) are cysts that occur within choroid plexus of the brain. The brain contains pockets or spaces called ventricles with a spongy layer of cells and blood vessels called the choroid plexus. This is in the middle of the fetal brain. The choroid plexus has the important function of producing a fluid called cerebrospinal fluid. The fluid produced by the cells of the choroid plexus fills the ventricles and then flows around the brain and the spinal cord to provide a cushion of fluid around these structures.
CPCs can form within this structure and come from fluid trapped within this spongy layer of cells, much like a soap bubble or a blister. CPCs are often called "soft signs" or fetal ultrasound "markers" because some studies have found a weak association between CPCs and fetal chromosome abnormalities.
It is believed that many adults have one or more tiny CPCs.[1] CPCs have no impact on an individual's health or development or learning. The fetal brain may create these cysts as a normal part of development. They are temporary and usually are gone by the 32nd week of pregnancy.
[edit] Chromosome problems
Genetic counseling is often recommended to provide more information about fetal CPCs, to answer questions and concerns, and to outline available options such as amniocentesis. There is a possible association between ultrasound-detected fetal CPCs and chromosome problems in the baby. Types of chromosome problems that are occasionally seen include Trisomy 18[2][3] or Trisomy 21 (Down syndrome).[4]
Generally the risks are low if there are no other risk factors. Some studies have estimated up to a 1% (1/100) chance of delivering a baby with a chromosome problem when there is a CPC present.
Other factors which may have a bearing on the baby's chances of developing chromosome problems include:
- mother's age at the expected date of delivery
- the results of serum screening; XAFP triple testing or quad screening
- evidence of other "fetal findings" seen at the time of the ultrasound that may suggest a chromosome problem
Many babies with chromosome problems do not show any signs on ultrasound.
[edit] References
- ^ Jeon JH, Lee SW, Ko JK, et al (2005). "Neuroendoscopic removal of large choroid plexus cyst: a case report". J. Korean Med. Sci. 20 (2): 335–9. PMID 15832013.
- ^ Hurt K, Sottner O, Záhumenský J, et al (2007). "[Choroid plexus cysts and risk of trisomy 18. Modifications regarding maternal age and markers]" (in Czech). Ceska Gynekol 72 (1): 49–52. PMID 17357350.
- ^ Papp C, Ban Z, Szigeti Z, Csaba A, Beke A, Papp Z (2007). "Role of second trimester sonography in detecting trisomy 18: a review of 70 cases". J Clin Ultrasound 35 (2): 68–72. doi:. PMID 17206726.
- ^ Dagklis T, Plasencia W, Maiz N, Duarte L, Nicolaides KH (2007). "Choroid plexus cyst, intracardiac echogenic focus, hyperechogenic bowel and hydronephrosis in screening for trisomy 21 at 11 + 0 to 13 + 6 weeks". Ultrasound Obstet Gynecol 31: 132. doi:. PMID 18085527.
