Chondroitin-glucuronate 5-epimerase

From Wikipedia, the free encyclopedia

In enzymology, a chondroitin-glucuronate 5-epimerase (EC 5.1.3.19) is an enzyme that catalyzes the chemical reaction

chondroitin D-glucuronate dermatan L-iduronate

Hence, this enzyme has one substrate, chondroitin D-glucuronate, and one product, dermatan L-iduronate.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is chondroitin-D-glucuronate 5-epimerase. Other names in common use include polyglucuronate 5-epimerase, dermatan-sulfate 5-epimerase, urunosyl C-5 epimerase, and chondroitin D-glucuronosyl 5-epimerase. This enzyme participates in chondroitin sulfate biosynthesis.

[edit] References

• IUBMB entry for 5.1.3.19
• BRENDA references for 5.1.3.19 (Recommended.)
• PubMed references for 5.1.3.19
• PubMed Central references for 5.1.3.19
• Google Scholar references for 5.1.3.19
• Malmstrom A, Aberg L (1982). "Biosynthesis of dermatan sulphate. Assay and properties of the uronosyl C-5 epimerase". Biochem. J. 201: 489–93. PMID 7092807. 

[edit] External links

The CAS registry number for this enzyme class is 86417-91-6.

• IUBMB entry for 5.1.3.19

• KEGG entry for 5.1.3.19

• BRENDA entry for 5.1.3.19

• NiceZyme view of 5.1.3.19

• EC2PDB: PDB structures for 5.1.3.19

• PRIAM entry for 5.1.3.19

• PUMA2 entry for 5.1.3.19

• IntEnz: Integrated Enzyme entry for 5.1.3.19

• MetaCyc entry for 5.1.3.19

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047757: chondroitin-glucuronate 5-epimerase

• AMIGO entry for GO code 0047757: chondroitin-glucuronate 5-epimerase