Chondro-4-sulfatase

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In enzymology, a chondro-4-sulfatase (EC 3.1.6.9) is an enzyme that catalyzes the chemical reaction

4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine 4-sulfate + H₂O $\rightleftharpoons$ 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine + sulfate

The 3 substrates of this enzyme are 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine, 4-sulfate, and H₂O, whereas its two products are 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine and sulfate.

This enzyme belongs to the family of hydrolases, specifically those acting on sulfuric ester bonds. The systematic name of this enzyme class is 4-deoxy-beta-D-gluc-4-enuronosyl-(1,3)-N-acetyl-D-galactosamine-4-su lfate 4-sulfohydrolase. This enzyme is also called chondroitin-4-sulfatase.

[edit] References

IUBMB entry for 3.1.6.9
BRENDA references for 3.1.6.9 (Recommended.)
PubMed references for 3.1.6.9
PubMed Central references for 3.1.6.9
Google Scholar references for 3.1.6.9
Held E, Buddecke E (1967). "[Studies on the chemistry of the arterial wall, XI. Demonstration, purification and properties of a chondroitin-4-sulfatase from bovine aorta]". Hoppe. Seylers. Z. Physiol. Chem. 348: 1047–60. PMID 5595107.
Roy AB (1976). "Sulphatases, lysosomes and disease". Aust. J. Exp. Biol. Med. Sci. 54: 111–35. doi:10.1038/icb.1976.13. PMID 13772.
Yamagata T, Saito H, Habuchi O, Suzuki S (1968). "Purification and properties of bacterial chondroitinases and chondrosulfatases". J. Biol. Chem. 243: 1523–35. PMID 5647268.