Choloyl-CoA hydrolase

From Wikipedia, the free encyclopedia

In enzymology, a choloyl-CoA hydrolase (EC 3.1.2.27) is an enzyme that catalyzes the chemical reaction

choloyl-CoA + H₂O cholate + CoA

Thus, the two substrates of this enzyme are choloyl-CoA and H₂O, whereas its two products are cholate and CoA.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is choloyl-CoA hydrolase. Other names in common use include PTE-2 (ambiguous), choloyl-coenzyme A thioesterase, chenodeoxycholoyl-coenzyme A thioesterase, and peroxisomal acyl-CoA thioesterase 2.

[edit] References

• IUBMB entry for 3.1.2.27
• BRENDA references for 3.1.2.27 (Recommended.)
• PubMed references for 3.1.2.27
• PubMed Central references for 3.1.2.27
• Google Scholar references for 3.1.2.27
• Hunt MC, Solaas K, Kase BF, Alexson SE (2002). "Characterization of an acyl-coA thioesterase that functions as a major regulator of peroxisomal lipid metabolism". J. Biol. Chem. 277: 1128–38. doi:10.1074/jbc.M106458200. PMID 11673457. 
• Solaas K, Sletta RJ, Soreide O, Kase BF (2000). "Presence of choloyl- and chenodeoxycholoyl-coenzyme A thioesterase activity in human liver". Scand. J. Clin. Lab. Invest. 60: 91–102. doi:10.1080/00365510050184903. PMID 10817395. 
• Russell DW (2003). "The enzymes, regulation, and genetics of bile acid synthesis". Annu. Rev. Biochem. 72: 137–74. doi:10.1146/annurev.biochem.72.121801.161712. PMID 12543708. 

[edit] External links

• IUBMB entry for 3.1.2.27

• KEGG entry for 3.1.2.27

• BRENDA entry for 3.1.2.27

• NiceZyme view of 3.1.2.27

• EC2PDB: PDB structures for 3.1.2.27

• PRIAM entry for 3.1.2.27

• PUMA2 entry for 3.1.2.27

• IntEnz: Integrated Enzyme entry for 3.1.2.27

• MetaCyc entry for 3.1.2.27

• Atomic-resolution structures of enzymes belonging to this class