Choline-phosphate cytidylyltransferase

From Wikipedia, the free encyclopedia

In enzymology, a choline-phosphate cytidylyltransferase (EC 2.7.7.15) is an enzyme that catalyzes the chemical reaction

CTP + choline phosphate diphosphate + CDP-choline

Thus, the two substrates of this enzyme are CTP and choline phosphate, whereas its two products are diphosphate and CDP-choline.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is CTP:choline-phosphate cytidylyltransferase. Other names in common use include phosphorylcholine transferase, CDP-choline pyrophosphorylase, CDP-choline synthetase, choline phosphate cytidylyltransferase, CTP-phosphocholine cytidylyltransferase, CTP:phosphorylcholine cytidylyltransferase, cytidine diphosphocholine pyrophosphorylase, phosphocholine cytidylyltransferase, phosphorylcholine cytidylyltransferase, and phosphorylcholine:CTP cytidylyltransferase. This enzyme participates in aminophosphonate metabolism and glycerophospholipid metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1PEH and 1PEI.

[edit] References

• IUBMB entry for 2.7.7.15
• BRENDA references for 2.7.7.15 (Recommended.)
• PubMed references for 2.7.7.15
• PubMed Central references for 2.7.7.15
• Google Scholar references for 2.7.7.15
• BORKENHAGEN LF, KENNEDY EP (1957). "The enzymatic synthesis of cytidine diphosphate choline". J. Biol. Chem. 227: 951–62. PMID 13463016. 
• KENNEDY EP, WEISS SB (1956). "The function of cytidine coenzymes in the biosynthesis of phospholipides". J. Biol. Chem. 222: 193–214. PMID 13366993. 
• Williams-Ashman HG and Banks J (1956). "Participation of cytidine coenzymes in the metabolism of choline by seminal vesicles". J. Biol. Chem. 223: 509–521. 

[edit] External links

The CAS registry number for this enzyme class is 9026-34-0.

• IUBMB entry for 2.7.7.15

• KEGG entry for 2.7.7.15

• BRENDA entry for 2.7.7.15

• NiceZyme view of 2.7.7.15

• EC2PDB: PDB structures for 2.7.7.15

• PRIAM entry for 2.7.7.15

• PUMA2 entry for 2.7.7.15

• IntEnz: Integrated Enzyme entry for 2.7.7.15

• MetaCyc entry for 2.7.7.15

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004105: choline-phosphate cytidylyltransferase

• AMIGO entry for GO code 0004105: choline-phosphate cytidylyltransferase