Cholestenone 5alpha-reductase

From Wikipedia, the free encyclopedia

In enzymology, a cholestenone 5alpha-reductase (EC 1.3.1.22) is an enzyme that catalyzes the chemical reaction

5alpha-cholestan-3-one + NADP⁺ cholest-4-en-3-one + NADPH + H⁺

Thus, the two substrates of this enzyme are 5alpha-cholestan-3-one and NADP⁺, whereas its 3 products are cholest-4-en-3-one, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-oxo-5alpha-steroid:NADP+ Delta4-oxidoreductase. Other names in common use include testosterone Delta4-5alpha-reductase, steroid 5alpha-reductase, 3-oxosteroid Delta4-dehydrogenase, 5alpha-reductase, steroid 5alpha-hydrogenase, 3-oxosteroid 5alpha-reductase, testosterone Delta4-hydrogenase, 4-ene-3-oxosteroid 5alpha-reductase, reduced nicotinamide adenine dinucleotide, phosphate:Delta4-3-ketosteroid 5alpha-oxidoreductase, 4-ene-5alpha-reductase, Delta4-3-ketosteroid 5alpha-oxidoreductase, cholest-4-en-3-one 5alpha-reductase, and testosterone 5alpha-reductase.

[edit] References

• IUBMB entry for 1.3.1.22
• BRENDA references for 1.3.1.22 (Recommended.)
• PubMed references for 1.3.1.22
• PubMed Central references for 1.3.1.22
• Google Scholar references for 1.3.1.22
• Shefer S, Hauser S, Mosbach EH (1966). "Studies on the biosynthesis of 5-alpha-cholestan-3-beta-ol. I Cholestenone 5-alpha-reductase of rat liver". J. Biol. Chem. 241: 946–52. PMID 5907469. 

[edit] External links

The CAS registry number for this enzyme class is 37255-34-8.

• IUBMB entry for 1.3.1.22

• KEGG entry for 1.3.1.22

• BRENDA entry for 1.3.1.22

• NiceZyme view of 1.3.1.22

• EC2PDB: PDB structures for 1.3.1.22

• PRIAM entry for 1.3.1.22

• PUMA2 entry for 1.3.1.22

• IntEnz: Integrated Enzyme entry for 1.3.1.22

• MetaCyc entry for 1.3.1.22

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047751: cholestenone 5-alpha-reductase

• AMIGO entry for GO code 0047751: cholestenone 5-alpha-reductase