Cholestenol Delta-isomerase

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In enzymology, a cholestenol Delta-isomerase (EC 5.3.3.5) is an enzyme that catalyzes the chemical reaction

5alpha-cholest-7-en-3beta-ol 5alpha-cholest-8-en-3beta-ol

Hence, this enzyme has one substrate, 5alpha-cholest-7-en-3beta-ol, and one product, 5alpha-cholest-8-en-3beta-ol.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is Delta7-cholestenol Delta7-Delta8-isomerase. This enzyme participates in biosynthesis of steroids.

[edit] References

• IUBMB entry for 5.3.3.5
• BRENDA references for 5.3.3.5 (Recommended.)
• PubMed references for 5.3.3.5
• PubMed Central references for 5.3.3.5
• Google Scholar references for 5.3.3.5
• Wilton DC, Rahimtula AD, Akhtar M (1969). "The reversibility of the delta8-cholestenol-delta7-cholestenol isomerase reaction in cholesterol biosynthesis". Biochem. J. 114: 71–3. PMID 5810070. 

[edit] External links

The CAS registry number for this enzyme class is 37318-47-1.

• IUBMB entry for 5.3.3.5

• KEGG entry for 5.3.3.5

• BRENDA entry for 5.3.3.5

• NiceZyme view of 5.3.3.5

• EC2PDB: PDB structures for 5.3.3.5

• PRIAM entry for 5.3.3.5

• PUMA2 entry for 5.3.3.5

• IntEnz: Integrated Enzyme entry for 5.3.3.5

• MetaCyc entry for 5.3.3.5

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047750: cholestenol delta-isomerase

• AMIGO entry for GO code 0047750: cholestenol delta-isomerase