Cholestanetetraol 26-dehydrogenase

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In enzymology, a cholestanetetraol 26-dehydrogenase (EC 1.1.1.161) is an enzyme that catalyzes the chemical reaction

(25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol + NAD⁺ $\rightleftharpoons$ (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al + NADH + H⁺

Thus, the two substrates of this enzyme are (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol and NAD⁺, whereas its 3 products are (25R)-3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-al, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (25R)-5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol:NAD+ 26-oxidoreductase. Other names in common use include cholestanetetrol 26-dehydrogenase, 5beta-cholestane-3alpha,7alpha,12alpha,26-tetrol dehydrogenase, TEHC-NAD oxidoreductase, 5beta-cholestane-3alpha,7alpha,12alpha,26-tetraol:NAD+, and 26-oxidoreductase. This enzyme participates in bile acid biosynthesis.

[edit] References

IUBMB entry for 1.1.1.161
BRENDA references for 1.1.1.161 (Recommended.)
PubMed references for 1.1.1.161
PubMed Central references for 1.1.1.161
Google Scholar references for 1.1.1.161
Masui T, Herman R, Staple E (1966). "The oxidation of 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha, 26-tetraol to 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol-26-oic acid via 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol-26-al by rat liver". Biochim. Biophys. Acta. 117: 266–8. PMID 5914340.