Cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase

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In enzymology, a cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase (EC 1.1.1.181) is an enzyme that catalyzes the chemical reaction

cholest-5-ene-3beta,7alpha-diol + NAD⁺ 7alpha-hydroxycholest-4-en-3-one + NADH + H⁺

Thus, the two substrates of this enzyme are cholest-5-ene-3beta,7alpha-diol and NAD⁺, whereas its 3 products are 7alpha-hydroxycholest-4-en-3-one, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cholest-5-ene-3beta,7alpha-diol:NAD+ 3-oxidoreductase. This enzyme is also called 3beta-hydroxy-Delta5-C27-steroid oxidoreductase. This enzyme participates in bile acid biosynthesis.

[edit] References

• IUBMB entry for 1.1.1.181
• BRENDA references for 1.1.1.181 (Recommended.)
• PubMed references for 1.1.1.181
• PubMed Central references for 1.1.1.181
• Google Scholar references for 1.1.1.181
• Wikvall K (1981). "Purification and properties of a 3 beta-hydroxy-delta 5-C27-steroid oxidoreductase from rabbit liver microsomes". J. Biol. Chem. 256: 3376–80. PMID 6937465. 

[edit] External links

The CAS registry number for this enzyme class is 56626-16-5.

• IUBMB entry for 1.1.1.181

• KEGG entry for 1.1.1.181

• BRENDA entry for 1.1.1.181

• NiceZyme view of 1.1.1.181

• EC2PDB: PDB structures for 1.1.1.181

• PRIAM entry for 1.1.1.181

• PUMA2 entry for 1.1.1.181

• IntEnz: Integrated Enzyme entry for 1.1.1.181

• MetaCyc entry for 1.1.1.181

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047016: cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase

• AMIGO entry for GO code 0047016: cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase