CHMP1A

From Wikipedia, the free encyclopedia

Procollagen (type III) N-endopeptidase

Identifiers

PCOLN3; CHMP1; CHMP1A; KIAA0047; PRSM1

External IDs

Gene ontology
Molecular Function:	• protein binding • metallopeptidase activity • zinc ion binding
Cellular Component:	• condensed nuclear chromosome • nucleus • early endosome • microtubule organizing center • endomembrane system • nuclear matrix
Biological Process:	• transcription • cell cycle • mitotic chromosome condensation • protein transport • vesicle-mediated transport • gene silencing • negative regulation of transcription by glucose • negative regulation of S phase of mitotic cell cycle • negative regulation of transcription, DNA-dependent

Orthologs

Human

Mouse

Entrez

5119

n/a

Refseq

NM_002768 (mRNA)
NP_002759 (protein)

n/a (mRNA)
n/a (protein)

Pubmed search

[1]

n/a

Procollagen (type III) N-endopeptidase, also known as PCOLN3, is a human gene.^[1]

This gene encodes a member of the CHMP/Chmp family of proteins which are involved in multivesicular body sorting of proteins to the interiors of lysosomes. The initial prediction of the protein sequence encoded by this gene suggested that the encoded protein was a metallopeptidase. The nomenclature has been updated recently to reflect the correct biological function of this encoded protein.^[1]

[edit] References

^ ^a ^b Entrez Gene: PCOLN3 procollagen (type III) N-endopeptidase.

[edit] Further reading

Nomura N, Nagase T, Miyajima N, et al. (1995). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 1 (5): 223-9. PMID 7584044.
Scott IC, Halila R, Jenkins JM, et al. (1996). "Molecular cloning, expression and chromosomal localization of a human gene encoding a 33 kDa putative metallopeptidase (PRSM1).". Gene 174 (1): 135-43. PMID 8863740.
Yoshida H, Haze K, Yanagi H, et al. (1999). "Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors.". J. Biol. Chem. 273 (50): 33741-9. PMID 9837962.
Stauffer DR, Howard TL, Nyun T, Hollenberg SM (2002). "CHMP1 is a novel nuclear matrix protein affecting chromatin structure and cell-cycle progression.". J. Cell. Sci. 114 (Pt 13): 2383-93. PMID 11559747.
Howard TL, Stauffer DR, Degnin CR, Hollenberg SM (2002). "CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins.". J. Cell. Sci. 114 (Pt 13): 2395-404. PMID 11559748.
Tong WY, Nagano-Fujii M, Hidajat R, et al. (2003). "Physical interaction between hepatitis C virus NS4B protein and CREB-RP/ATF6beta.". Biochem. Biophys. Res. Commun. 299 (3): 366-72. PMID 12445808.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Strack B, Calistri A, Craig S, et al. (2003). "AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding.". Cell 114 (6): 689-99. PMID 14505569.
von Schwedler UK, Stuchell M, Müller B, et al. (2003). "The protein network of HIV budding.". Cell 114 (6): 701-13. PMID 14505570.
Martin-Serrano J, Yarovoy A, Perez-Caballero D, et al. (2003). "Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins.". Proc. Natl. Acad. Sci. U.S.A. 100 (21): 12414-9. doi:10.1073/pnas.2133846100. PMID 14519844.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.
Row PE, Liu H, Hayes S, et al. (2007). "The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation.". J. Biol. Chem. 282 (42): 30929-37. doi:10.1074/jbc.M704009200. PMID 17711858.