Talk:Chlorphenamine

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Contents 1 This was plagarised 2 Which was the model for zimelidine? 3 SSRI template/category? 4 SSRI potency 5 First-generation? 6 P450 Contradiction 7 Citation for half-life?

[edit] This was plagarised

A straight copy-paste from http://www.answers.com/topic/chlorphenamine

Actually, moron, if you read the page, answers.com copied and pasted from Wikipedia! It's very clearly cited at the bottom. —Preceding unsigned comment added by 198.108.140.10 (talk) 05:45, 11 September 2007 (UTC)

Now now, insulting people isn't nice. Please be polite. An uninformed individual might think that answers.com is more official and reliable than Wikipedia, but Wikipedians know better. Fuzzform 23:09, 31 October 2007 (UTC)

[edit] Which was the model for zimelidine?

The articles diphenhydramine and zimelidine claim that diphenhydramine, not chlorpheniramine, was used as a model for zimelidine. However, googling returns 146 matches for chlorpheniramine zimelidine, or 21 for chlorphenamine zimelidine (Swedish 12 for klorfeniramin zimelidin) but only 119 for diphenhydramine zimelidine (Swedish 13 for difenhydramin zimelidin). Which should it be? On Wpedia diphenhydramine is the one most mentioned.

Where next Columbus? 00:29, 17 December 2005 (UTC).

As I understand it, zimelidine was synthesized from chlorpheniramine. But, as diphenhydramine is by far the most common antihistamine (and probably also the basis for the synthesis of chlorpheniramine, although I haven't seen any papers confirming that), it may as well be said that zimelidine was based off of diphenhydramine. In other words, chlorpheniramine was an intermediate between diphenhydramine and zimelidine. Fuzzform 23:07, 31 October 2007 (UTC)

Actually, it was brompheniramine that was the basis for zimelidine. See (circa) page 50 in Baronde's book "Better Than Prozac". 24.218.74.249 (talk) 04:31, 19 April 2008 (UTC)

[edit] SSRI template/category?

Should this be on the antidepressant template under SSRIs? It's already in the SSRI category, but it seems a little strange since it isn't used as an antidepressant. Thoughts? --Galaxiaad 18:47, 6 November 2006 (UTC)

I don't think so. As you say, it isn't used as an antidepressant. It's main use is as an antihistamine, and that's the template it belongs in. Fuzzform 23:00, 31 October 2007 (UTC)

[edit] SSRI potency

Is this potent enough that people taking SSRIs or MAOIs etc. should avoid it?

Unlikely. It's main effect is antagonism of histamine H₁ (see antihistamine). Also, I'm about to update the image from png to svg. Note that the CH₃ (methyl) groups about the nitrogen are implied in the skeletal formula and need not be written as such. Fuzzform 22:59, 31 October 2007 (UTC)

[edit] First-generation?

In the first paragraph which says that Chlorphenamine is a first-generation antihistamine, what does "first-generation" mean? Cat Dancer WS (talk) 00:36, 28 January 2008 (UTC)

1st generation antihistamines usually have sedative effects, aside from that, I cannot define them any more, but usually 1st generation antihistamines (this being the exception) aren't used for allergies any more. —Preceding unsigned comment added by 89.241.171.89 (talk) 18:32, 3 March 2008 (UTC)

I linked first-generation to the relevant article and section. These drugs are still widely used. They include Benadryl, OTC sleep aids, and Dramamine. Hopefully this will answer your questions. --Jmcclare (talk) 03:21, 10 April 2008 (UTC)

[edit] P450 Contradiction

Okay, I'm a little puzzled. Chlorphenamine says it potentiates certain opioid analgesics (including codeine), but according to CYP2D6 chlorphenamine is an inhibitor of this P450 isozyme, while codeine is a substrate. Codeine states that it is a prodrug, being converted (via CYP2D6) into the active metabolites. How can chlorphenamine potentiate codeine when it inhibits the enzyme responsible for codeine's activity? --Jmcclare (talk) 03:30, 10 April 2008 (UTC)

Antihistamines are certainly potentiators of opiods - no question about that. Either there is mistake in the CYP2D6 article, or there is some other (stronger/more important) mechanism to explain antihistamines' potentiation of opiods. 24.218.74.249 (talk) 04:36, 19 April 2008 (UTC)

[edit] Citation for half-life?

In the pharmacokinetic data, chlorphenamine has a stated half-life of 21-27 hours. However, standard Chlor-Trimeton and generics state that they are effective for 4 hours. There are 8 and 12-hour versions, but these are a sustained relief formulation. If it takes 21-27 hours for the body to metabolize and excrete 50% of a chlorphenamine dose, how can it no longer be effective after 4 hours? I don't see a citation on the article which would cover this half-life claim, so I wonder if it could be incorrect.

Can anyone clarify this or add a citation? Thanks. Josh274 (talk) 00:38, 10 June 2008 (UTC)

Generally such info held by DrugBank link provided in the infobox, except DrugBank site currently seems temporarily down :-( David Ruben ^Talk 13:22, 10 June 2008 (UTC)