Chlorphentermine

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Chlorphentermine
Systematic (IUPAC) name
1-(4-chlorophenyl)-2-methylpropan-2-amine
Identifiers
CAS number	461-78-9 151-06-4 (HCl)
ATC code	A08AA
PubChem	10007
Chemical data
Formula	C10H14ClN
Mol. mass	183.68 g/mol
Synonyms	p-Chloro-α,α-dimethylphenethylamine
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	40 hours
Excretion	Renal
Therapeutic considerations
Pregnancy cat.	?
Legal status
Routes	Oral

Chlorphentermine (trade names Apsedon, Desopimon, Lucofen) is a stimulant drug which was used as an appetite suppressant. Developed in 1962, it is the 4-chloro derivative of the better known appetite suppressant phentermine,^[1] which is still in current use.

Chlorphentermine itself is a relatively weak stimulant with little abuse potential, but is classed as a Schedule 3 drug in the USA due mainly to its similarity to other appetite suppressants such as diethylpropion which have been more widely abused. It is no longer used due mainly to safety concerns, as it has a serotonergic effects profile similar to other withdrawn appetite suppressants such as fenfluramine and aminorex which were found to cause pulmonary hypertension and cardiac fibrosis following prolonged use.^[2]

[edit] References

1. ^ Gylys JA, Hart JJ, Warren MR. Chlorphentermine, a new anorectic agent. Journal of Pharmacology and Experimental Therapeutics. 1962 Sep;137:365-73.
2. ^ Rothman RB, Ayestas MA, Dersch CM, Baumann MH. Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension. Circulation. 1999 Aug 24;100(8):869-75.

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