Chloromuconate cycloisomerase

From Wikipedia, the free encyclopedia

In enzymology, a chloromuconate cycloisomerase (EC 5.5.1.7) is an enzyme that catalyzes the chemical reaction

2-chloro-2,5-dihydro-5-oxofuran-2-acetate 3-chloro-cis,cis-muconate

Hence, this enzyme has one substrate, 2-chloro-2,5-dihydro-5-oxofuran-2-acetate, and one product, 3-chloro-cis,cis-muconate.

This enzyme belongs to the family of isomerases, specifically the class of intramolecular lyases. The systematic name of this enzyme class is 2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing). This enzyme is also called muconate cycloisomerase II. This enzyme participates in gamma-hexachlorocyclohexane degradation and 1,4-dichlorobenzene degradation. It employs one cofactor, manganese.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1CHR, 1NU5, and 2CHR.

[edit] References

• IUBMB entry for 5.5.1.7
• BRENDA references for 5.5.1.7 (Recommended.)
• PubMed references for 5.5.1.7
• PubMed Central references for 5.5.1.7
• Google Scholar references for 5.5.1.7
• Schmidt E, Knackmuss HJ (1980). "Chemical structure and biodegradability of halogenated aromatic compounds. Conversion of chlorinated muconic acids into maleoylacetic acid". Biochem. J. 192: 339–47. PMID 7305906. 

[edit] External links

The CAS registry number for this enzyme class is 95990-33-3.

• IUBMB entry for 5.5.1.7

• KEGG entry for 5.5.1.7

• BRENDA entry for 5.5.1.7

• NiceZyme view of 5.5.1.7

• EC2PDB: PDB structures for 5.5.1.7

• PRIAM entry for 5.5.1.7

• PUMA2 entry for 5.5.1.7

• IntEnz: Integrated Enzyme entry for 5.5.1.7

• MetaCyc entry for 5.5.1.7

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0018850: chloromuconate cycloisomerase

• AMIGO entry for GO code 0018850: chloromuconate cycloisomerase