Chloride potassium symporter 5

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Solute carrier family 12, (potassium-chloride transporter) member 5
Identifiers
Symbol(s) SLC12A5; KCC2; KIAA1176
External IDs OMIM: 606726 MGI: 1862037 HomoloGene: 10665
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 57468 57138
Ensembl ENSG00000124140 ENSMUSG00000017740
Uniprot Q9H2X9 Q3UHQ2
Refseq NM_020708 (mRNA)
NP_065759 (protein)		 NM_020333 (mRNA)
NP_065066 (protein)
Location Chr 20: 44.09 - 44.12 Mb Chr 2: 164.66 - 164.69 Mb
Pubmed search [1] [2]

potassium-chloride transporter member 5 is a type of chloride potassium symporter.

This potassium-chloride transporter is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons.[1]

It is encoded by the gene SLC12A5, is a human gene.[1]

[edit] See also

[edit] References

  1. ^ a b Entrez Gene: SLC12A5 solute carrier family 12, (potassium-chloride transporter) member 5.

[edit] Further reading

  • Hebert SC, Mount DB, Gamba G (2004). "Molecular physiology of cation-coupled Cl- cotransport: the SLC12 family.". Pflugers Arch. 447 (5): 580-93. doi:10.1007/s00424-003-1066-3. PMID 12739168. 
  • Rivera C, Voipio J, Kaila K (2005). "Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII.". J. Physiol. (Lond.) 562 (Pt 1): 27-36. doi:10.1113/jphysiol.2004.077495. PMID 15528236. 
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353-8. PMID 9110174. 
  • Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.". DNA Res. 6 (5): 329-36. PMID 10574461. 
  • Hübner CA, Stein V, Hermans-Borgmeyer I, et al. (2001). "Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition.". Neuron 30 (2): 515-24. PMID 11395011. 
  • Sallinen R, Tornberg J, Putkiranta M, et al. (2001). "Chromosomal localization of SLC12A5/Slc12a5, the human and mouse genes for the neuron-specific K(+)-Cl(-) cotransporter (KCC2) defines a new region of conserved homology.". Cytogenet. Cell Genet. 94 (1-2): 67-70. PMID 11701957. 
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052. 
  • Song L, Mercado A, Vázquez N, et al. (2002). "Molecular, functional, and genomic characterization of human KCC2, the neuronal K-Cl cotransporter.". Brain Res. Mol. Brain Res. 103 (1-2): 91-105. PMID 12106695. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Bräuer M, Frei E, Claes L, et al. (2003). "Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts.". Am. J. Physiol., Cell Physiol. 285 (1): C22-30. doi:10.1152/ajpcell.00289.2002. PMID 12637262. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Lee H, Chen CX, Liu YJ, et al. (2005). "KCC2 expression in immature rat cortical neurons is sufficient to switch the polarity of GABA responses.". Eur. J. Neurosci. 21 (9): 2593-9. doi:10.1111/j.1460-9568.2005.04084.x. PMID 15932617. 
  • Mercado A, Broumand V, Zandi-Nejad K, et al. (2006). "A C-terminal domain in KCC2 confers constitutive K+-Cl- cotransport.". J. Biol. Chem. 281 (2): 1016-26. doi:10.1074/jbc.M509972200. PMID 16291749. 
  • Vanhatalo S, Palva JM, Andersson S, et al. (2006). "Slow endogenous activity transients and developmental expression of K+-Cl- cotransporter 2 in the immature human cortex.". Eur. J. Neurosci. 22 (11): 2799-804. doi:10.1111/j.1460-9568.2005.04459.x. PMID 16324114. 
  • Lee HH, Walker JA, Williams JR, et al. (2007). "Direct protein kinase C-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter KCC2.". J. Biol. Chem. 282 (41): 29777-84. doi:10.1074/jbc.M705053200. PMID 17693402. 
  • Uvarov P, Ludwig A, Markkanen M, et al. (2007). "A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2.". J. Biol. Chem. 282 (42): 30570-6. doi:10.1074/jbc.M705095200. PMID 17715129. 
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Membrane proteins, carrier proteins: membrane transport proteins
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B2-3, B2, B3, B4, B5, B6, B7, B9, B11

C1, C2, C3, C4, C5, C6, C8, C8-9, C10, C13, C11

D1, D2, D3, D4, E1, F1, F2

G1, G2, G4, Sterolin (G5, G8)
Solute carrier
1A1-7, 1A1, 1A2, 1A3, 1A4, 1A5, 2A1, 2A2, 2A3, 2A4, 2A5, 2A6, 2A8, 2A9, 2A10, 2A12, 3A1, 3A2, 4A1, 4A2, 4A3, 4A4, 4A5, 4A7, 4A8, 4A11, 5A1-2, 5A1, 5A3, 5A5, 5A8, 6A1, 6A2, 6A3, 6A4, 6A5, 6A8, 6A9, 6A19, 7A1, 7A2, 7A3, 7A4, 7A5, 7A7, 7A8, 7A9, 7A11, 8A1-3, 9A1, 9A2, 9A3, 9A3R1, 9A3R2, 9A5, 9A6, 9A8, 10A1, 10A2, 10A3, 10A7, 11A1, 11A2, 11A3, 12A1-2, 12A3, 12A4, 12A5, 12A6, 12A7, 14A1, 13A3, 14A2, 15A1, 15A2, 16A1, 16A2, 16A3, 16A4, 17A1, 17A5, 17A6-8, 17A7, 18A1, 18A2, 18A3, 19A1, 19A2, 19A3, 20A1, 20A2, 22A1, 22A2, 22A3, 22A4, 22A5, 22A6, 22A7, 22A9, 22A11, 22A12, 22A18, 23A1, 23A2, 24A1-2, 24A5, 25A1, 25A3, 25A4, 25A4-6, 25A8, 25A10, 25A11, 25A12, 25A13, 25A14, 25A15, 25A17, 25A19, 25A20, 25A27, 25A31, 25A37, 25A39, 26A2, 26A3, 26A4, 26A5, 26A6, 26A7, 26A8, 27A1, 27A2, 27A3, 27A4, 28A1, 28A2, 29A1, 29A2, 29A4, 30A4, 30A7, 30A8, 31A1, 31A2, 32A1, 34A1, 34A2, 34A3, 35A1, 35A2, 35B2, 35B4, 35C1, 36A1, 37A4, 38A2, 38A3, 39A1, 39A2, 39A3, 39A4, 39A6, 39A7, 40A1, 43A1 44A1, 44A2, 44A4, 45A2, O1A2, O1B1, O1B3, O2B1, O431, O4A1
Monosaccharide
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Membrane transport protein: ion pumps
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